田口徹 | | 新潟医療福祉大学

リハビリテーション学部

Department of Physical Therapy 理学療法学科

教員紹介

田口徹写真

田口徹 Toru Taguchi

教授

プロフィール

担当科目	生理学Ⅰ・Ⅱ、生理学実習Ⅰ・Ⅱ、痛み学、理学療法学概論
専門分野	疼痛学、生理学、神経科学、理学療法学
キーワード	イオンチャネル; メカノバイオロジー; 感作; 脊髄; 筋膜; c-Fos; 単一神経記録; 肩こり; 腰痛; 筋緊張性頭痛; 痛覚過敏; 遅発性筋痛; 線維筋痛症; 筋・筋膜性疼痛; 侵害受容器; 痛み
学位・称号／取得機関／取得年	博士（医学）／名古屋大学／2005年
資格	1999 理学療法士
所属団体・学会等	日本生理学会、日本神経科学学会、日本疼痛学会、国際疼痛学会、日本理学療法士協会、日本基礎理学療法学会、日本体力医学会

外部リンク

業績等

研究領域	筋・筋膜性疼痛の生理・病態・治療
研究紹介	肩こりや腰痛、膝の痛みは「国民病」であり、未だ原因や適切な治療が確立していない慢性難治性の病態です。患者の日常生活を制限するだけでなく、超高齢社会を迎えた現在、医療経済的にも重要な国家的課題となっています。私はこのような痛みの発生源として筋や筋膜組織に注目し、「筋・筋膜性疼痛」のメカニズム解明に取り組んでいます。また、筋・筋膜性疼痛に対して、理学療法による治療効果を実証し、その鎮痛機構の解明を目指しています。
著書	1. 水村和枝, 矢島弘毅, 田口徹, 佐藤純. 痛み研究のアプローチ. 皮膚・筋―神経標本からの単一神経記録による検討法. 河谷正仁. 真興交易（株）医書出版部. 2006 pp88-96 2. Mizumura K, Taguchi T. FUNDAMENTALS OF MUSCULOSKELETAL PAIN. Facilitated response of muscle thin-fiber receptors in mechanical hyperalgesia after exercise. Arendt-Nielsen L, Graven-Nielsen T, Mense S. IASP Press. 2008 pp47-59 (Part 1, Chapter 4) 3. 田口徹．日本マイオセラピー協会ニュースレター. 筋痛研究の最前線. 日本マイオセラピー協会. 2009 10(1): 10-17 4. 田口徹．慢性疼痛における薬剤選定と治療薬開発. 線維筋痛症の発症・病態メカニズムと今後の展望. 技術情報協会. 2010 pp131-134 5. Hoheisel U, Taguchi T, Mense S. Fascia: The Tensional Network of the Human Body. The thoracolumbar fascia as a sensory organ. Schleip R, Findley T, Chaitow L, Huijing P. Elsevier. 2012 pp95-101 (Chapter 2-4) 6. Katanosaka K, Murase S, Taguchi T, Mizumura K. Recent Advances in Mechanobiology. Neural mechanisms and developmental process of mechanically induced pain -insights obtained from the study on the mechanical hyperalgesia after exercise (delayed onset muscle soreness)-. Shanghai Scientific and Technological Literature Publishing House. 2012 pp181-188 7. Taguchi T, Mizumura K. Pain Models: Translational Relevance and Applications. Analysis of nociceptors with muscle- and viscera-nerve preparations in vitro. Handwerker H, Arendt-Nielsen L. IASP Press. 2013 pp47-60 (Chapter 2-4) 8. Hoheisel U, Taguchi T, Mense S. Lehrbuch Faszien. Nociception – die Fascia thoracolumbalis als sensorisches Organ. Schleip R, Findley TW, Chaitow L, Huijing PA. Urban & Fischer Verlag. 2014 pp 69-74 9. Mizumura K, Taguchi T. Musculoskeletal Pain - Basic Mechanisms and Implications. Facilitated mechanical response of muscle nociceptors after exercise: Involvement of neurotrophic factors. Graven-Nielsen T, Arendt-Nielsen L. IASP Press. 2014 pp223-236 (Part II, Chapter 15) 10. Taguchi T, Mizumura K. Musculoskeletal Pain - Basic Mechanisms and Implications. Peripheral fascial nociceptors and their spinal projections. Graven-Nielsen T, Arendt-Nielsen L. IASP Press. 2014 pp173-186 (Part II, Chapter 12) 11. 田口徹．痛みのメカニズムとこれからの治療薬・治療法の開発. 遅発性筋痛の神経・分子機構. 技術情報協会. 2015 pp160-164 (第3章, 第10節) 12. 田口徹. Pain Research. モデル動物を用いた線維筋痛症の病態機構解明. 日本疼痛学会. 2017 32(1): 19-24 13. 田口徹. 動物／疾患モデルの作製技術・病態解析・評価手法. 線維筋痛症の最新メカニズムと創薬への応用. 技術情報協会. 2017 pp368-374 (8章, 第6節) 14. 田口徹. 動物／疾患モデルの作製技術・病態解析・評価手法. 線維筋痛症モデルの作製手法. 技術情報協会. 2017 pp339-344 (8章, 第2節) 15. 田口徹, 歌大介, 若月康次. 日本運動器疼痛学会誌. 線維筋痛症のメカニズムを紐解く. 「特集: 動物実験だからこそ得られた痛み研究の知見」. 日本運動器疼痛学会. 2017 9(2): 182-187 16. 歌大介, 田口徹. Pain Research. 線維筋痛症モデルラットにおける末梢及び脊髄の侵害情報伝達機構. 日本疼痛学会. 2017 32(4): 280-287 17. 水村和枝, 田口徹. 基礎老化研究. 筋・筋膜の痛みの末梢性メカニズムと老化「体性感覚と老化の生理学～「痛み」を中心に～」. 日本基礎老化学会. 2018 42(1): 13-20 18. 田口徹, 太田大樹, 若月康次, 濱上陽平. ペインクリニック. 筋・筋膜性疼痛および線維筋痛症の末梢神経機構. 真興交易（株）医書出版部. 2018 39巻別冊春号: S61-S68 19. 田口徹. 日本臨牀. 線維筋痛症のモデル動物「特集：線維筋痛症ー最新の基礎・臨床知見ー」. 日本臨牀社. 2018 76(11): 1943-1948 20. 田口徹. リハビリテーション神経科学. 痛みの末梢神経・脊髄機構. 鈴木俊明, 大西秀明. メジカルビュー社. 2019 pp72-89 (Part 1, 5章) 21. 田口徹. 理学療法ジャーナル. 線維筋痛症. 1ページ講座：理学療法関連用語～正しい意味がわかりますか？医学書院. 2019 53(4): 389 22. 田口徹. Modern Physician. 線維筋痛症について教えてください. ペイン・リハ実践：コモン・ディジーズQ&A. 特集：実践！ペイン・リハ—慢性疼痛治療の変革. 新興医学出版社. 2019 39(6): 589-591 23. 田口徹. 疼痛医学 (パイロット版). 基礎科学：運動器の痛みのメカニズム：筋痛. 第II編２章１）. 医学書院. 2020 pp59-64 24. 田口徹. 疼痛医学. 基礎科学：運動器の痛みのメカニズム：筋痛. 第II編２章１）. 医学書院. 2021 pp61-66 25. 田口徹. いたみの教科書「疼痛医学」ダイジェスト版. 基礎科学：運動器の痛みのメカニズム：筋痛. 第II編２章１）. 医学書院. 2021 pp24-25 26. Hoheisel U, Taguchi T, Mense S. Fascia: The Tensional Network of the Human Body (2nd eds): The Science and Clinical Applications in Manual and Movement Therapy. Nociception: the thoracolumbar and crural fascia as sensory organs. Schleip R, Stecco C, Driscoll M, Huijing P. Elsevier. 2021 pp179-187 27. 田口徹. ペインクリニック. 筋・筋膜性疼痛の特徴とメカニズム. 真興交易（株）医書出版部. 2022 43(5): 505-513 28. 田口徹. 日本運動器疼痛学会誌. 遅発性筋痛の機構をめぐる最新知見. 特集：「疼痛基礎科学アップデート」. 日本運動器疼痛学会. 2022 14(3): 194-202 29. 田口徹. ペインクリニック. ストレス誘発性疼痛の末梢神経・脊髄機構. 真興交易（株）医書出版部. 2022 43(12): 1319-1327
受賞歴	1. 2005 若手学術優秀賞, ポリモーダルクラブ 2. 2007 若手優秀論文賞, 名古屋大学環境医学研究所学術企画評価広報委員会 3. 2008 研究奨励賞, 上原記念生命科学財団 4. 2010 Early Career Award, 国際疼痛学会 5. 2012 優秀演題賞, 第4回日本線維筋痛症学会
研究論文（英文）	1. Taguchi T, Sato J, Mizumura K. A combination of eccentric muscle exercise and repeated cold stress (RCS) induced prolonged hyperalgesia: An attempt to develop an animal model of chronic muscle pain. Environ Med 2002 46(1,2): 74-76. 2. Taguchi T, Matsuda T, Tamura R, Sato J, Mizumura K. Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats. J Physiol (Lond.) 2005 564(Pt 1): 259-268. 3. Taguchi T, Sato J, Mizumura K. Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction. J Neurophysiol 2005 94(4): 2822-2831. 4. Takahashi K, Taguchi T, Itoh K, Okada K, Kawakita K, Mizumura K. Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes. Somatos Mot Res 2005 22(4): 299-305. 5. Taguchi T, John V, Hoheisel U, Mense S. Neuroanatomical pathway of nociception originating in a low back muscle (multifidus) in the rat. Neurosci Lett 2007 427(1): 22-27. 6. Taguchi T, Hoheisel U, Mense S. Neuroanatomy and electrophysiology of low back pain: Experiments on rats. Akt Neurol 2007 34(8): 472-477. 7. Taguchi T, Matsuda T, Mizumura K. Change with age in muscular mechanical hyperalgesia after lengthening contraction in rats. Neurosci Res 2007 57(3): 331-338. 8. Taguchi T, Hoheisel U, Mense S. Dorsal horn neurons having input from low back structures in rats. Pain 2008 138(1): 119-129. 9. Fujii Y, Ozaki N, Taguchi T, Mizumura K, Furukawa K, Sugiura Y. TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness. Pain 2008 140(2): 292-304. 10. Taguchi T, Kozaki Y, Katanosaka K, Mizumura K. Compression-induced ATP release from rat skeletal muscle with and without lengthening contraction. Neurosci Lett 2008 434(3): 277-281. 11. Taguchi T, Tomotoshi K, Mizumura K. Excitatory actions of mushroom poison (acromelic acid) on unmyelinated muscular afferents in the rat. Neurosci Lett 2009 456(2): 69-73. 12. Gibson W, Arendt-Nielsen L, Taguchi T, Mizumura K, Graven-Nielsen T. Increased pain from muscle fascia following eccentric exercise: Animal and human findings. Exp Brain Res 2009 194(2): 299-308. 13. Murase S, Terazawa E, Queme F, Ota H, Matsuda T, Hirate K, Kozaki Y, Katanosaka K, Taguchi T, Urai H, Mizumura K. Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed onset muscle soreness). J Neurosci 2010 30(10):3752-3761. 14. Hotta N, Taguchi T, Mizumura K. Low pH enhances the response of thin muscle afferents to mechanical stimuli. Adv Exp Med Biol 2010 669: 315-318. 15. Mizumura K, Murase S, Taguchi T. Animal models of myofascial trigger points. J Musculoskelet Pain 2010 18(4): 361-366. 16. Nasu T, Taguchi T, Mizumura K. Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. Eur J Pain 2010 14(3): 236-244. 17. Taguchi T, Ota H, Matsuda T, Murase S, Mizumura K. Cutaneous C-fiber nociceptor responses and nociceptive behaviors in aged Sprague-Dawley rats. Pain 2010 151(3): 771-782. 18. Hoheisel U, Taguchi T, Treede R-D, Mense S. Nociceptive input from the rat thoracolumbar fascia to lumbar dorsal horn neurones. Eur J Pain 2011 15(8): 810-815. 19. Takahashi K, Taguchi T, Tanaka S, Sadato N, Qiu Y, Kakigi R, Mizumura K. Painful muscle stimulation preferentially activates emotion-related brain regions compared to painful skin stimulation. Neurosci Res 2011 70(3): 285-293. 20. Taguchi T, Mizumura K. Augmented mechanical response of muscular thin-fiber receptors in aged rats recorded in vitro. Eur J Pain 2011 15(4): 351-358. 21. Queme F, Taguchi T, Mizumura K, Graven-Nielsen T. Muscular heat and mechanical pain sensitivity after lengthening contractions in humans and animals. J Pain 2013 14(11): 1425-1436. 22. Taguchi T, Yasui M, Kubo A, Abe M, Kiyama H, Yamanaka A, Mizumura K. Nociception originating from the crural fascia in rats. Pain 2013 154(7): 1103-1114. 23. Murase S, Terazawa E, Hirate K, Yamanaka H, Kanda H, Noguchi K, Ota H, Queme F, Taguchi T, Mizumura K. Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats. J Physiol (Lond.) 2013 591(Pt 12): 3035-3048. 24. Mori T, Agata N, Itoh Y, Miyazu-Inoue M, Sokabe M, Taguchi T, Kawakami K. Stretch speed-dependent myofibre damage and functional deficits in rat skeletal muscle induced by lengthening contraction. Physiol Rep 2014 2(11): e12213. 25. Murase S, Kato K, Taguchi T, Mizumura K. Glial cell line-derived neurotrophic factor sensitized the mechanical response of muscular thin-fibre afferents in rats. Eur J Pain 2014 18(5): 629-638. 26. Kubo A, Taguchi T, Mizumura K. Monocyte chemoattractant protein-1-induced excitation and sensitization to mechanical stimulation of mechanosensitive C-fiber afferents in rat skin. Neurosci Res 2015 91: 13-18. 27. Taguchi T, Katanosaka K, Yasui M, Hayashi K, Yamashita M, Wakatsuki K, Kiyama H, Yamanaka A, Mizumura K. Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain 2015 156(3): 415-427. 28. Urakawa S, Takamoto K, Kanemoto M, Nakamura T, Sakai S, Matsuda T, Taguchi T, Mizumura K, Ono T, Nishijo H. Manual therapy ameliorates delayed-onset muscle soreness and alters muscle metabolites in rats. Physiol Rep 2015 3(2): e12279. 29. Matsuda T, Kubo A, Taguchi T, Mizumura K. ATP decreases mechanical sensitivity of muscle thin-fiber afferents in rats. Neurosci Res 2015 97: 36-44. 30. Mizumura K, Taguchi T. Delayed onset muscle soreness: Involvement of neurotrophic factors. J Physiol Sci 2016 66(1): 43-52. 31. Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Okura M, Taguchi T, Yamanaka A. The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation. Sci Rep 2016 6: 29480. 32. Morikawa Y, Takamoto K, Nishimaru H, Taguchi T, Urakawa S, Sakai S, Ono T, Nishijo H. Compression at myofascial trigger point on chronic neck pain provides immediate pain relief through the prefrontal cortex and autonomic nervous system: a pilot study. Front Neurosci 2017 11: 186. 33. Hayashi K, Katanosaka K, Abe M, Yamanaka A, Nosaka K, Mizumura K, Taguchi T. Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion. Eur J Pain 2017 21(1): 125-139. 34. Takamoto K, Saitoh T, Taguchi T, Nishimaru H, Urakawa S, Sakai S, Ono T, Nishijo H. Lip closure training improves eating behaviors and prefrontal cortical hemodynamic activity and decreases daytime sleep in elderly persons. J Bodyw Mov Ther 2018 22(3): 810-816. 35. Mori T, Agata N, Itoh Y, Miyazu-Inoue M, Sokabe M, Taguchi T, Kawakami K (co-corresponding author). Post-injury stretch promotes recovery in a rat model of muscle damage induced by lengthening contractions. J Physiol Sci 2018 68(4): 483-492. 36. Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H, Yasaka T. Interleukin-27 controls basal pain threshold in physiological and pathological conditions. Sci Rep 2018 8: 11022. 37. Cheng CC, Tsutsui K, Taguchi T (*co-first author), Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. Hair follicle epidermal stem cells define a niche for tactile sensation. Elife 2018 7: e38883. 38. Shimodaira T, Mikoshiba S, Taguchi T. Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats. PLoS One 2019 14(11): e0224809. 39. Matsubara T, Hayashi K, Wakatsuki K, Abe M, Ozaki N, Yamanaka A, Mizumura K, Taguchi T. Thin-fiber receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise. Eur J Pain 2019 23(10): 1801-1813. 40. Wakatsuki K, Takeda-Uchimura Y, Matsubara T, Nasu T, Mizumura K, Taguchi T. Peripheral nociceptive mechanisms in an experimental rat model of fibromyalgia induced by repeated cold stress. Neurosci Res 2020 162: 22-30. 41. Tsuboshima K, Urakawa S, Takamoto K, Taguchi T, Matsuda T, Sakai S, Mizumura K, Ono T, Nishijo H. Distinct effects of thermal treatments after lengthening contraction on mechanical hyperalgesia and exercise-induced physiological changes in rat muscle. J Appl Physiol 2020 128: 296-306. 42. Miyahara K, Nishimaru H, Matsumoto J, Setogawa T, Taguchi T, Ono T, Nishijo H. Involvement of parvalbumin-positive neurons in the development of hyperalgesia in a mouse model of fibromyalgia. Front Pain Res 2021 2: 627860. 43. Murase S, Kobayashi K, Nasu T, Kihara C, Taguchi T, Mizumura K. Synergistic interaction of nerve growth factor and glial cell-line derived neurotrophic factor in muscular mechanical hyperalgesia in rats. J Physiol (Lond.) 2021 599(6): 1783-1798. 44. Ota H, Takebe H, Mizumura K, Taguchi T Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats. J Physiol Sci 2021 71(1): 19. 45. Murase S, Kobayashi K, Nasu T, Kihara C, Taguchi T, Mizumura K. Reply to 'Letter to the Editor; Characterization of muscle afferents’. J Physiol (Lond.) 2021 599(17): 4227-4229. 46. Uta D, Tsuboshima K, Nishijo H, Mizumura K, Taguchi T. Neuronal sensitization and synaptic facilitation in the superficial dorsal horn of a rat reserpine-induced pain model. Neuroscience 2021 479: 125-139. 47. Ejiri Y, Uta D, Ota H, Mizumura K, Taguchi T. Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. Neurosci Res 2021 181: 87-94. 48. Hanada K, Ota H, Mizumura K, Taguchi T. Pressure pain threshold map of thoracolumbar paraspinal muscles after lengthening contractions in young male asymptomatic volunteers. Sci Rep 2022 12: 15825.
研究論文（和文）	1. 田口徹, 講武芳英, 松原貴子, 三木明徳. 下り坂走行後のマウス下腿三頭筋における血行動態の経時的変化. 理学療法の医学的基礎研究会雑誌. 2000 4(2): 25-32. 2. 水村和枝, 田口徹. 痛み受容器をめぐる最近の話題 ―痛み受容器における受容変換機構と筋肉痛モデルにおける痛み受容器活動の変化― 特集「筋・骨格系の痛み研究の最近の話題」. 運動療法と物理療法. 2004 15(3): 176-182. 3. 田口徹. 筋・筋膜性疼痛の末梢神経機構. SYMPOSIA (Web版), 日本生理学雑誌. 2014 76(3)(Pt2): 61. 4. 田口徹. 筋肉の痛み、筋膜の痛み. 生体制御学会誌. 2014 29: 2-13. 5. 阿部真博, 林功栄, 若月康次, 田口徹. ラット筋機械痛覚過敏に対するネオビタカイン®の鎮痛効果. ペインクリニック. 2017 38(5): 645-654. 6. 宮原謙一郎, 若月康次, 坪島功幸, 太田大樹, 片野坂公明, 水村和枝, 西条寿夫, 田口徹. レセルピン投与による線維筋痛症モデルラットにおける骨格筋の組織学的変化. 理学療法学. 2022 49(4): 306-312. 7. 井上創太, 太田大樹, 田口徹. 社会的敗北ストレスモデルラットでは侵害刺激に対する脊髄後角表層ニューロンの興奮性が増大する. 基礎理学療法学. 2022 25(1): 35-42. 8. 太田大樹, 大井理史, 片野坂公明, 田口徹. 遅発性筋痛モデルラットの筋におけるTACAN発現変化の部位差. Pain Research. 2022 37(3): 153-156.
科学研究費	1. 2008-2010 その他遅発性筋痛モデルによる筋性疼痛の中枢機構に関する研究 2. 2011-2012 その他筋・筋膜における非活動性侵害受容器の役割とその活性化機構に関する研究 3. 2011-2013 基盤研究（B）筋性疼痛における各種神経栄養因子の関与と筋における産生・作用機構 4. 2012-2013 その他筋肉痛の診断と治療効果を可視化・可聴化する医療デバイスの開発 5. 2012-2014 挑戦的研究（萌芽）痛み（感覚）センサーとしての筋膜の新たな基礎医学的役割の確立 6. 2013-2015 基盤研究（B）ストレス誘発性筋・筋膜性疼痛の神経機構解明とその治療 7. 2014-2016 基盤研究（B）痛覚感作物質産生組織としての筋の特性の解析 8. 2016-2017 挑戦的研究（萌芽）侵害受容器特異的活動操作による効果器機能の実証と疼痛制御 9. 2016-2018 挑戦的研究（萌芽）筋膜を基軸とした痛覚過敏機構の解明とその治療 10. 2016-2021 その他機械受容応答を支える膜・糖鎖環境の解明と筋疾患治療への展開 11. 2017-2019 基盤研究（C）骨格筋損傷に有効な寒冷・温熱療法の刺激条件とは? 12. 2019-2021 基盤研究（C）新規in vivoパッチクランプ法を用いた慢性筋痛の脊髄機構解明と治療薬の探索 13. 2019-2021 基盤研究（B）遅発性筋痛の神経・分子機構解明とその理学療法効果の実証 14. 2022-2024 基盤研究（B）ストレス誘発性疼痛の中枢機構解明と理学療法効果の実証
共同研究・受託研究等	1. 2003 研究助成金 Existence of muscular tenderness revealed by behavioral pain test and c-Fos expression after eccentric muscular contraction in rats. 2. 2007 研究助成金遅発性筋痛（いわゆる運動後の筋肉痛）における神経成長因子の関与 3. 2008 研究助成金筋性疼痛モデルにおける筋ポリモーダル受容器の機械感作機構の解析 4. 2008 研究助成金 Role of Nerve Growth Factor (NGF) in Animal Models of Acute and Chronic Muscle Pain 5. 2008 研究助成金キノコ毒（アクロメリン酸）の末梢痛み（侵害）受容器における作用機構の探索 6. 2010 研究助成金 Muscular and fascial nociceptors: Do we know all types? 7. 2010 研究助成金アクロメリン酸による末梢侵害受容器の興奮・感作機構の解明 8. 2010 研究助成金筋・筋膜における非活動性侵害受容器の役割 9. 2010 研究助成金筋・筋膜における非活動性侵害受容器の役割とその活性化機構の探索 10. 2011 研究助成金線維筋痛症の末梢、および中枢神経機構の解明 11. 2011 研究助成金線維筋痛症の病態メカニズム解明に関する多角的研究 12. 2012-2014 企業共同筋・筋膜性疼痛の神経機構に関する研究 13. 2012 その他単一神経記録法によるラット侵害受容器活動の電気生理学的記録法・解析法 14. 2012 研究助成金痛覚過敏におけるsilent nociceptorの役割とその活性化機構の解明 15. 2012-2013 研究助成金筋・筋膜自発電気活動の記録・解析：鍼の客観的診断・治療への応用 16. 2013 研究助成金筋膜は侵害受容を担う感覚組織である 17. 2014 研究助成金遅発性筋痛の決定因子とその神経・分子機構 18. 2014 研究助成金運動不足による慢性痛発症機構の解明と光遺伝学を用いた新規治療法の試み 19. 2014 研究助成金骨格筋のin vivo光操作によるサルコペニア関連疾患の治療 20. 2015 研究助成金感覚神経の光遺伝学操作による疼痛制御法の開発 21. 2016 研究助成金線維筋痛症をモデルとした慢性難治性疼痛の病態機構解明と治療 22. 2019-2023 企業共同慢性運動器疼痛の理学療法のための教育モデルおよび教育拠点の構築 23. 2023 企業共同電気生理学的手法を用いた筋痙攣モデルの作製と漢方薬の評価
学会・職能団体の委員	1. 2011 日本生理学会評議員 2. 2019 日本疼痛学会代議員 3. 2021 日本基礎理学療法学会評議員
学内委員会活動	1. 筋性疼痛研究会世話人

Profile

Research Areas	Neuroscience, Sensory Physiology, Pain, Sports and Rehabilitation Sciences
Research Introduction	1. Physiology, pathophysiology, and treatment of musculoskeletal pain 2. Molecular and neural mechanisms of mechanical hyperalgesia 3. Adaptation mechanisms of skeletal muscle in response to exercise 4. Novel physiological roles of "muscle fascia"
Books	1. Mizumura K, Taguchi T. Facilitated response of muscle thin-fiber receptors in mechanical hyperalgesia after exercise. In: Arendt-Nielsen L, Graven-Nielsen T and Mense S eds, FUNDAMENTALS OF MUSCULOSKELETAL PAIN (Part 1, Chapter 4, pp47-59) Seattle, IASP Press, 2008. 2. Hoheisel U, Taguchi T, Mense S. “Nociception: The thoracolumbar fascia as a sensory organ”. In: Fascia: The Tensional Network of the Human Body (eds) Schleip R, Findley T, Chaitow L and Huijing P, Chapter 2-4, pp95-101, Churchill Livingstone, Elsevier, 2012. 3. Katanosaka K, Murase S, Taguchi T, Mizumura K. Neural mechanisms and developmental process of mechanically induced pain -insights obtained from the study on the mechanical hyperalgesia after exercise (delayed onset muscle soreness)-. Recent Advances in Mechanobiology pp181-188, Shanghai Scientific and Technological Literature Publishing House, 2012. 4. Taguchi T, Mizumura K. Analysis of nociceptors with muscle- and viscera-nerve preparations in vitro. In: Handwerker H and Arendt-Nielsen L eds, Pain Models: Translational Relevance and Applications (Chapter 2-4, pp47-60) Washington, D.C., IASP Press, 2013. 5. Hoheisel U, Taguchi T, Mense S. Nociception – die Fascia thoracolumbalis als sensorisches Organ. In: Schleip R, Findley TW, Chaitow L, Huijing PA (Eds.). Lehrbuch Faszien, pp 69-74, Urban & Fischer Verlag, München, 2014. 6. Taguchi T, Mizumura K. Peripheral fascial nociceptors and their spinal projections. In: Graven-Nielsen T and Arendt-Nielsen L eds, Musculoskeletal Pain - Basic Mechanisms and Implications (Part II, Chapter 12, pp173-186) Washington, D.C., IASP Press, 2014. 7. Mizumura K, Taguchi T. Facilitated mechanical response of muscle nociceptors after exercise: Involvement of neurotrophic factors. In: Graven-Nielsen T and Arendt-Nielsen L eds, Musculoskeletal Pain: Basic Mechanisms and Implications (Part II, Chapter 15, pp223-236) Washington, D.C., IASP Press, 2014. 8. Hoheisel U, Taguchi T, Mense S. Nociception: the thoracolumbar and crural fascia as sensory organs. In: Fascia: The Tensional Network of the Human Body (2nd eds): The Science and Clinical Applications in Manual and Movement Therapy. Schleip R, Stecco C, Driscoll M, Huijing P, Chapter 2.4, pp179-187, Elsevier, 2021.
Papers	1. Taguchi T, Sato J, Mizumura K. A combination of eccentric muscle exercise and repeated cold stress (RCS) induced prolonged hyperalgesia: An attempt to develop an animal model of chronic muscle pain. Environ Med 2002 46(1,2): 74-76. 2. Taguchi T, Matsuda T, Tamura R, Sato J, Mizumura K. Muscular mechanical hyperalgesia revealed by behavioural pain test and c-Fos expression in the spinal dorsal horn after eccentric contraction in rats. J Physiol (Lond.) 2005 564(Pt 1): 259-268. 3. Taguchi T, Sato J, Mizumura K. Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle-nerve preparations in vitro after eccentric contraction. J Neurophysiol 2005 94(4): 2822-2831. 4. Takahashi K, Taguchi T, Itoh K, Okada K, Kawakita K, Mizumura K. Influence of surface anesthesia on the pressure pain threshold measured with different-sized probes. Somatos Mot Res 2005 22(4): 299-305. 5. Taguchi T, John V, Hoheisel U, Mense S. Neuroanatomical pathway of nociception originating in a low back muscle (multifidus) in the rat. Neurosci Lett 2007 427(1): 22-27. 6. Taguchi T, Hoheisel U, Mense S. Neuroanatomy and electrophysiology of low back pain: Experiments on rats. Akt Neurol 2007 34(8): 472-477. 7. Taguchi T, Matsuda T, Mizumura K. Change with age in muscular mechanical hyperalgesia after lengthening contraction in rats. Neurosci Res 2007 57(3): 331-338. 8. Taguchi T, Hoheisel U, Mense S. Dorsal horn neurons having input from low back structures in rats. Pain 2008 138(1): 119-129. 9. Fujii Y, Ozaki N, Taguchi T, Mizumura K, Furukawa K, Sugiura Y. TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness. Pain 2008 140(2): 292-304. 10. Taguchi T, Kozaki Y, Katanosaka K, Mizumura K. Compression-induced ATP release from rat skeletal muscle with and without lengthening contraction. Neurosci Lett 2008 434(3): 277-281. 11. Taguchi T, Tomotoshi K, Mizumura K. Excitatory actions of mushroom poison (acromelic acid) on unmyelinated muscular afferents in the rat. Neurosci Lett 2009 456(2): 69-73. 12. Gibson W, Arendt-Nielsen L, Taguchi T, Mizumura K, Graven-Nielsen T. Increased pain from muscle fascia following eccentric exercise: Animal and human findings. Exp Brain Res 2009 194(2): 299-308. 13. Murase S, Terazawa E, Queme F, Ota H, Matsuda T, Hirate K, Kozaki Y, Katanosaka K, Taguchi T, Urai H, Mizumura K. Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed onset muscle soreness). J Neurosci 2010 30(10):3752-3761. 14. Hotta N, Taguchi T, Mizumura K. Low pH enhances the response of thin muscle afferents to mechanical stimuli. Adv Exp Med Biol 2010 669: 315-318. 15. Mizumura K, Murase S, Taguchi T. Animal models of myofascial trigger points. J Musculoskelet Pain 2010 18(4): 361-366. 16. Nasu T, Taguchi T, Mizumura K. Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. Eur J Pain 2010 14(3): 236-244. 17. Taguchi T, Ota H, Matsuda T, Murase S, Mizumura K. Cutaneous C-fiber nociceptor responses and nociceptive behaviors in aged Sprague-Dawley rats. Pain 2010 151(3): 771-782. 18. Hoheisel U, Taguchi T, Treede R-D, Mense S. Nociceptive input from the rat thoracolumbar fascia to lumbar dorsal horn neurones. Eur J Pain 2011 15(8): 810-815. 19. Takahashi K, Taguchi T, Tanaka S, Sadato N, Qiu Y, Kakigi R, Mizumura K. Painful muscle stimulation preferentially activates emotion-related brain regions compared to painful skin stimulation. Neurosci Res 2011 70(3): 285-293. 20. Taguchi T, Mizumura K. Augmented mechanical response of muscular thin-fiber receptors in aged rats recorded in vitro. Eur J Pain 2011 15(4): 351-358. 21. Queme F, Taguchi T, Mizumura K, Graven-Nielsen T. Muscular heat and mechanical pain sensitivity after lengthening contractions in humans and animals. J Pain 2013 14(11): 1425-1436. 22. Taguchi T, Yasui M, Kubo A, Abe M, Kiyama H, Yamanaka A, Mizumura K. Nociception originating from the crural fascia in rats. Pain 2013 154(7): 1103-1114. 23. Murase S, Terazawa E, Hirate K, Yamanaka H, Kanda H, Noguchi K, Ota H, Queme F, Taguchi T, Mizumura K. Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats. J Physiol (Lond.) 2013 591(Pt 12): 3035-3048. 24. Mori T, Agata N, Itoh Y, Miyazu-Inoue M, Sokabe M, Taguchi T, Kawakami K. Stretch speed-dependent myofibre damage and functional deficits in rat skeletal muscle induced by lengthening contraction. Physiol Rep 2014 2(11): e12213. 25. Murase S, Kato K, Taguchi T, Mizumura K. Glial cell line-derived neurotrophic factor sensitized the mechanical response of muscular thin-fibre afferents in rats. Eur J Pain 2014 18(5): 629-638. 26. Kubo A, Taguchi T, Mizumura K. Monocyte chemoattractant protein-1-induced excitation and sensitization to mechanical stimulation of mechanosensitive C-fiber afferents in rat skin. Neurosci Res 2015 91: 13-18. 27. Taguchi T, Katanosaka K, Yasui M, Hayashi K, Yamashita M, Wakatsuki K, Kiyama H, Yamanaka A, Mizumura K. Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model. Pain 2015 156(3): 415-427. 28. Urakawa S, Takamoto K, Kanemoto M, Nakamura T, Sakai S, Matsuda T, Taguchi T, Mizumura K, Ono T, Nishijo H. Manual therapy ameliorates delayed-onset muscle soreness and alters muscle metabolites in rats. Physiol Rep 2015 3(2): e12279. 29. Matsuda T, Kubo A, Taguchi T, Mizumura K. ATP decreases mechanical sensitivity of muscle thin-fiber afferents in rats. Neurosci Res 2015 97: 36-44. 30. Mizumura K, Taguchi T. Delayed onset muscle soreness: Involvement of neurotrophic factors. J Physiol Sci 2016 66(1): 43-52. 31. Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Okura M, Taguchi T, Yamanaka A. The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation. Sci Rep 2016 6: 29480. 32. Morikawa Y, Takamoto K, Nishimaru H, Taguchi T, Urakawa S, Sakai S, Ono T, Nishijo H. Compression at myofascial trigger point on chronic neck pain provides immediate pain relief through the prefrontal cortex and autonomic nervous system: a pilot study. Front Neurosci 2017 11: 186. 33. Hayashi K, Katanosaka K, Abe M, Yamanaka A, Nosaka K, Mizumura K, Taguchi T. Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion. Eur J Pain 2017 21(1): 125-139. 34. Takamoto K, Saitoh T, Taguchi T, Nishimaru H, Urakawa S, Sakai S, Ono T, Nishijo H. Lip closure training improves eating behaviors and prefrontal cortical hemodynamic activity and decreases daytime sleep in elderly persons. J Bodyw Mov Ther 2018 22(3): 810-816. 35. Mori T, Agata N, Itoh Y, Miyazu-Inoue M, Sokabe M, Taguchi T, Kawakami K (co-corresponding author). Post-injury stretch promotes recovery in a rat model of muscle damage induced by lengthening contractions. J Physiol Sci 2018 68(4): 483-492. 36. Sasaguri T, Taguchi T, Murata Y, Kobayashi K, Iizasa S, Iizasa E, Tsuda M, Hirakawa N, Hara H, Yoshida H, Yasaka T. Interleukin-27 controls basal pain threshold in physiological and pathological conditions. Sci Rep 2018 8: 11022. 37. Cheng CC, Tsutsui K, Taguchi T (*co-first author), Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H. Hair follicle epidermal stem cells define a niche for tactile sensation. Elife 2018 7: e38883. 38. Shimodaira T, Mikoshiba S, Taguchi T. Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats. PLoS One 2019 14(11): e0224809. 39. Matsubara T, Hayashi K, Wakatsuki K, Abe M, Ozaki N, Yamanaka A, Mizumura K, Taguchi T. Thin-fiber receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise. Eur J Pain 2019 23(10): 1801-1813. 40. Wakatsuki K, Takeda-Uchimura Y, Matsubara T, Nasu T, Mizumura K, Taguchi T. Peripheral nociceptive mechanisms in an experimental rat model of fibromyalgia induced by repeated cold stress. Neurosci Res 2020 162: 22-30. 41. Tsuboshima K, Urakawa S, Takamoto K, Taguchi T, Matsuda T, Sakai S, Mizumura K, Ono T, Nishijo H. Distinct effects of thermal treatments after lengthening contraction on mechanical hyperalgesia and exercise-induced physiological changes in rat muscle. J Appl Physiol 2020 128: 296-306. 42. Miyahara K, Nishimaru H, Matsumoto J, Setogawa T, Taguchi T, Ono T, Nishijo H. Involvement of parvalbumin-positive neurons in the development of hyperalgesia in a mouse model of fibromyalgia. Front Pain Res 2021 2: 627860. 43. Murase S, Kobayashi K, Nasu T, Kihara C, Taguchi T, Mizumura K. Synergistic interaction of nerve growth factor and glial cell-line derived neurotrophic factor in muscular mechanical hyperalgesia in rats. J Physiol (Lond.) 2021 599(6): 1783-1798. 44. Ota H, Takebe H, Mizumura K, Taguchi T Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats. J Physiol Sci 2021 71(1): 19. 45. Murase S, Kobayashi K, Nasu T, Kihara C, Taguchi T, Mizumura K. Reply to 'Letter to the Editor; Characterization of muscle afferents’. J Physiol (Lond.) 2021 599(17): 4227-4229. 46. Uta D, Tsuboshima K, Nishijo H, Mizumura K, Taguchi T. Neuronal sensitization and synaptic facilitation in the superficial dorsal horn of a rat reserpine-induced pain model. Neuroscience 2021 479: 125-139. 47. Ejiri Y, Uta D, Ota H, Mizumura K, Taguchi T. Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. Neurosci Res 2021 181: 87-94. 48. Hanada K, Ota H, Mizumura K, Taguchi T. Pressure pain threshold map of thoracolumbar paraspinal muscles after lengthening contractions in young male asymptomatic volunteers. Sci Rep 2022 12: 15825.