田村典子 | | 新潟医療福祉大学

健康科学部

Department of Health and Nutrition 健康栄養学科

教員紹介

田村典子写真

健康科学部／健康栄養学科
Faculty of Health Sciences／Department of Health and Nutrition

田村典子 Noriko Tamura

教授

プロフィール

担当科目	生化学Ⅰ、生化学Ⅱ、生化学実験、食品衛生学、食品衛生学実験, 実験の基礎
専門分野	生化学、細胞生理学
キーワード	血小板　血栓
学位・称号／取得機関／取得年	博士（医学）／東海大学／2005年修士（農学）／千葉大学／1996年
資格	1994年度中学・高等学校教諭一種免許（理科）
過去の経歴	（株）特殊免疫研究所、東海大学、自治医科大学を経て現職
所属団体・学会等	日本血栓止血学会、日本バイオレオロジー学会、日本機能性食品医用学会

外部リンク

業績等

研究領域	蛍光顕微鏡を用いた血小板の活性化および血小板血栓のリアルタイムイメージング
研究紹介	エコノミークラス症候群のように、長時間ずっと同じ姿勢で座り込んでいると血液循環が悪くなり、血栓ができやすくなります。血小板は怪我をした時など血管内で血栓をつくり止血をする働きをしますが、その血栓も過剰にできれば心筋梗塞や肺梗塞などかえって人にダメージを与えることになります。血栓形成には血球細胞（特に赤血球と血小板）と凝固因子、そして血流の３条件が必須です。本研究ではヒト、または動物の血液を用いて、血流条件下で血小板血栓の成長過程を蛍光顕微鏡でイメージングします。どのような食物を摂取したときに血小板血栓の形成に影響を及ぼすのか、血栓予防につながるのかを研究しています。
受賞歴	1. 2005年国際血栓止血学会young investigator賞
研究論文（英文）	1. Tamura N, Goto S, Yokota H, Goto S. Contributing Role of Mitochondrial Energy Metabolism on Platelet Adhesion, Activation and Thrombus Formation under Blood Flow Conditions. Platelets 2022 DOI: https://doi.org/10.1080/09537104.2022.2046722 2. Tamura N, Shimizu K, Shiozaki S, Sugiyama K, Nakayama M, Goto S, Takagi S, Goto S. Important regulatory Role of Erythrocytes on Platelet Adhesion to the von Willebrand Factor on the Wall Under Blood Conditions. Thrombus Haemost. 2021 DOI:10.1055/a-1677-9499 3. Kawamura Y, Tamura N, Goto S, Goto S. Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them. J Interv Cardiol, 2021. doi: 10.1155/2021/8880988 4. Goto S, Tamura N, Ayabe K, Kato E, Hasebe T, Takagi S, Kawamura Y, Goto S. A methods and preliminary results of in silico computer　simulation　for　the　formation　of　mix　thrombi　with　platelete　and　fibrin. J　Biolrheol. 2017; 31(2):30-34. 5. Nakajima K, Fujita J, Matsui M, Tohyama S, Tamura N, Kanazawa H, Seki T, Kishino Y, Hirano A, Okada M, Tabei R, Sano M, Goto S, Tabata Y, Fukuda K. Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function after Myocardial Infarction. PLoS One. 2015 Jul 17; 10(7)　 6. Tomita A, Tamura N, Nanazawa Y, Shiozaki S, Goto S. Development of virtual platelets implementing the functions of three platelet membrane proteins with different adhesive characteristics. J Atheroscler Thromb. 2015; 22(2):201-10 7. Baghai M, Tamura N, Beyersdorf F, Henze M, Prucker O, Ruhe J, Goto S, Zieger B, Heilmann C. Platelet repellent properties of hydrogel coatings on polyurethane-coated glass surfaces. ASAIO J. 2014; 60(5):587-93. 　 8. Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S. Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries. J Atheroscler Thromb. 2010; 17(5):536. 9. Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest. 2010 Jan; 120(1):179-90 10. Toda E, Ishida H, Aoki T, Urano T, Takahari Y, Tamura N, Goto S. Possible mechanism of preventive effects of coffee intake on the formation of arterial occlusive thrombosis. Tokai J Exp Clin Med. 2010 20;35(4):133-6. 11. Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S. Important regulatory role of activated platelet-derived procoagrant activity in the propagation of thrombi formed under arterial blood flow conditions. Circ J. 2009; 73(3):540-8. 12. Eguchi Y, Takahari Y, Higashijima N, Ishizuka N, Tamura N, Kawamura Y, H.Ishida. Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production. Circ J. 2009 Mar; 73(3):554-61. 13. Moriguchi GS, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y. ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions. Atherosclerosis. 2009 Apr; 203(2):409-16. 14. Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware ZJ, Nakauchi H. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med. 2008 Aug 4; 205(8):1917-27. Epub 15. Jin W, Inoue O, Tamura N, Inoue SK, Satoh K , Berndt MC, Handa M, Goto S, Ozaki Y A role for glycosphingolipid-enriched microdomains in platelet glycoprotein Ib-mediated platelet activation. Journal of Thrombosis Haemostasis. 2007 May; 5(5):1034-40. 16. Goto S, Tamura N, Ishida H. Ruggeri ZM. Dependence of Platelete Thronbus Stabirity on Sustained Glycoprotein IIb/IIIa Activation Through Adennosine 5'-Diphosphate Receptor Stimulation and Cyclic Calcium Signaling. Journal of the American College of Cardiology. 2006; 47: 155-62 17. Kojima H, Moroi M, Jung SM, Goto S, Tamura N, Kozuma T, Suzukawa K, Nagasawa T. Characterization of a Patient with Glycoprotein(GP)VI Deficiency Processing Neither Anti-GPVI Autoantibody nor Genetic Aberration. Journal of Thrombosis and Haemostasis. 2006; 4: 2433-42
科学研究費	1. 2011-2013年 490万基盤研究（C）「カルシウムイオンナノレベルイメージングによる血小板内活性化機能に関する研究」
学会等研究発表	1. 清水瑳羅,佐藤万理亜,山下夢朗,小林栞莉,平井美由紀,田村典子血小板血栓の初期形成過程に及ぼすポリフェノールの効果第46回日本バイオレオロジー学会年会 6月 2. 佐藤万理亜,清水瑳羅,山下夢朗,小林栞莉,平井美由紀,田村典子 Flow chamberを用いた血小板機能評価によるフォンブルブランド因子の精製佐藤万理亜,清水瑳羅,山下夢朗,小林栞莉,平井美由紀,田村典子第23回新潟医療福祉学会総会 11月 3. 田村典子, 平井美由紀, 小林栞莉ケルセチン・ルテオリンによる血小板血栓形成の抑制効果第23回新潟栄養・食文化学会 12月
学会・職能団体の委員	1. 2023, 2024年度日本血栓止血学会代議員
学内委員会活動	1. 図書館学習支援委員会, 遺伝子組換え実験安全委員会, メンタルヘルス支援委員

Profile

Research Areas	Cell Biology, Biorheology
Research Introduction	Study on the mechanism of platelet thrombus formation, Study on the functional food with anti-thrombosis.
Papers	1. Tamura N, Goto S, Yokota H, Goto S. Contributing Role of Mitochondrial Energy Metabolism on Platelet Adhesion, Activation and Thrombus Formation under Blood Flow Conditions. Platelets 2022 DOI: https://doi.org/10.1080/09537104.2022.2046722 2. Tamura N, Shimizu K, Shiozaki S, Sugiyama K, Nakayama M, Goto S, Takagi S, Goto S. Important regulatory Role of Erythrocytes on Platelet Adhesion to the von Willebrand Factor on the Wall Under Blood Conditions. Thrombus Haemost. 2021 DOI:10.1055/a-1677-9499 3. Kawamura Y, Tamura N, Goto S, Goto S. Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them. J Interv Cardiol, 2021. doi: 10.1155/2021/8880988 4. Goto S, Tamura N, Ayabe K, Kato E, Hasebe T, Takagi S, Kawamura Y, Goto S. A methods and preliminary results of in silico computer　simulation　for　the　formation　of　mix　thrombi　with　platelete　and　fibrin. J　Biolrheol. 2017; 31(2):30-34. 5. Nakajima K, Fujita J, Matsui M, Tohyama S, Tamura N, Kanazawa H, Seki T, Kishino Y, Hirano A, Okada M, Tabei R, Sano M, Goto S, Tabata Y, Fukuda K. Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function after Myocardial Infarction. PLoS One. 2015 Jul 17; 10(7)　 6. Tomita A, Tamura N, Nanazawa Y, Shiozaki S, Goto S. Development of virtual platelets implementing the functions of three platelet membrane proteins with different adhesive characteristics. J Atheroscler Thromb. 2015; 22(2):201-10 7. Baghai M, Tamura N, Beyersdorf F, Henze M, Prucker O, Ruhe J, Goto S, Zieger B, Heilmann C. Platelet repellent properties of hydrogel coatings on polyurethane-coated glass surfaces. ASAIO J. 2014; 60(5):587-93. 　 8. Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S. Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries. J Atheroscler Thromb. 2010; 17(5):536. 9. Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest. 2010 Jan; 120(1):179-90 10. Toda E, Ishida H, Aoki T, Urano T, Takahari Y, Tamura N, Goto S. Possible mechanism of preventive effects of coffee intake on the formation of arterial occlusive thrombosis. Tokai J Exp Clin Med. 2010 20;35(4):133-6. 11. Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S. Important regulatory role of activated platelet-derived procoagrant activity in the propagation of thrombi formed under arterial blood flow conditions. Circ J. 2009; 73(3):540-8. 12. Eguchi Y, Takahari Y, Higashijima N, Ishizuka N, Tamura N, Kawamura Y, H.Ishida. Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production. Circ J. 2009 Mar; 73(3):554-61. 13. Moriguchi GS, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y. ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions. Atherosclerosis. 2009 Apr; 203(2):409-16. 14. Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware ZJ, Nakauchi H. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med. 2008 Aug 4; 205(8):1917-27. Epub 15. Jin W, Inoue O, Tamura N, Inoue SK, Satoh K , Berndt MC, Handa M, Goto S, Ozaki Y A role for glycosphingolipid-enriched microdomains in platelet glycoprotein Ib-mediated platelet activation. Journal of Thrombosis Haemostasis. 2007 May; 5(5):1034-40. 16. Goto S, Tamura N, Ishida H. Ruggeri ZM. Dependence of Platelete Thronbus Stabirity on Sustained Glycoprotein IIb/IIIa Activation Through Adennosine 5'-Diphosphate Receptor Stimulation and Cyclic Calcium Signaling. Journal of the American College of Cardiology. 2006; 47: 155-62 17. Kojima H, Moroi M, Jung SM, Goto S, Tamura N, Kozuma T, Suzukawa K, Nagasawa T. Characterization of a Patient with Glycoprotein(GP)VI Deficiency Processing Neither Anti-GPVI Autoantibody nor Genetic Aberration. Journal of Thrombosis and Haemostasis. 2006; 4: 2433-42 1) Tamura N, Goto S, Yokota H, Goto S.Contributing role of mitochondrial energy metabolism on platelet adhesion, activation, and thrombus formation under blood flow conditions. Platelets. 33(7): 1083–1089. 2022 2) Tamura N, Shimizu K, Shiozaki S, Sugiyama K, Nakayama M, Goto S, Takagi S, Goto S. Important regulatory Role of Erythrocytes on Platelet Adhesion to the von Willebrand Factor on the Wall Under Blood Conditions. Thrombus Haemost 2021. DOI:10.1055/a-1677-9499 3) Kawamura Y, Tamura N, Goto S, Goto S. Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them. J Interv Cardiol, doi: 10.1155/2021/8880988 4) Goto S, Tamura N, Ayabe K, Kato E, Hasebe T, Takagi S, Kawamura Y, Goto S. A methods and preliminary results of in silico computer simulation for the formation of mix thrombi with platelet and fibrin. J Biolrheol. 2017;31(2):30-34. 5) Nakajima K, Fujita J, Matsui M, Tohyama S, Tamura N, Kanazawa H, Seki T, Kishino Y, Hirano A, Okada M, Tabei R, Sano M, Goto S, Tabata Y, Fukuda K. Gelatin Hydrogel Enhances the Engraftment of Transplanted Cardiomyocytes and Angiogenesis to Ameliorate Cardiac Function after Myocardial Infarction. PLoS One. 2015 Jul 17;10(7) 6) Tomita A, Tamura N, Nanazawa Y, Shiozaki S, Goto S.Development of virtual platelets implementing the functions of three platelet membrane proteins with different adhesive characteristics. J Artheroscler Thromb. 2015;22(2):201-10 7) Baghai M, Tamura N, Beyersdorf F, Henze M, Prucker O, Ruhe J, Goto S, Zieger B, Heilmann C. Platelet repellent properties of hydrogel coatings on polyurethane-coated glass surfaces. ASAIO J.　2014;60(5):587-93. 8) Kawamura Y, Takahari Y, Tamura N, Eguchi Y, Urano T, Ishida H, Goto S. Imaging of structural changes in endothelial cells and thrombus formation at the site of FeCl(3)-induced injuries in mice cremasteric arteries. J Artheroscler Thromb.2010;17(5):536. 9) Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIb beta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest. 2010 Jan;120(1):179-90 10) Toda E, Ishida H, Aoki T, Urano T, Takahari Y, Tamura N, Goto S. Possible mechanism of preventive effects of coffee intake on the formation of arterial occlusive thrombosis. Tokai J Exp Clin Med. 2010 20;35(4):133-6. 11) Tamura N, Kitajima I, Kawamura Y, Toda E, Eguchi Y, Ishida H, Goto S. Important regulatory role of activated platelet-derived procoagrant activity in the propagation of thrombi formed under arterial blood flow conditions. Circ J. 2009;73(3):540-8. 12) Eguchi Y, Takahari Y, Higashijima N, Ishizuka N, Tamura N, Kawamura Y, H.Ishida. Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production. Circ J. 2009 Mar;73(3):554-61. 13) Moriguchi GS, Yamashita A, Tamura N, Soejima K, Takahashi M, Nakagaki T, Goto S, Asada Y. ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions. Atherosclerosis. 2009 Apr;203(2):409-16. 14) Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware ZJ, Nakauchi H. Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells. J Exp Med. 2008 Aug 4;205(8):1917-27. Epub 2008 15) Jin W, Inoue O, Tamura N, Inoue SK, Satoh K , Berndt MC, Handa M, Goto S, Ozaki Y A role for glycosphingolipid-enriched microdomains in platelet glycoprotein Ib-mediated platelet activation. Journal of Thrombosis Haemostasis. 2007 May;5(5):1034-40. 16) Goto S, Tamura N, Ishida H. Ruggeri ZM. Dependence of Platelet Thrombus Stability on Sustained Glycoprotein IIb/IIIa Activation Through Adenosine 5'-Diphosphate Receptor Stimulation and Cyclic Calcium Signaling. Journal of the American College of Cardiology. 2006; 47: 155-62 17) Kojima H, Moroi M, Jung SM, Goto S, Tamura N, Kozuma T, Suzukawa K, Nagasawa T. Characterization of a Patient with Glycoprotein(GP)VI Deficiency Processing Neither Anti-GPVI Autoantibody nor Genetic Aberration. Journal of Thrombosis and Haemostasis. 2006; 4: 2433-42 18) Goto S, Tamura N, Ishida H. Ruggeri ZM. Dependence of Platelet Thrombus Stability on Sustained Glycoprotein IIb/IIIa Activation Through Adenosine 5'-Diphosphate Receptor Stimulation and Cyclic Calcium Signaling. Journal of the American College of Cardiology 2006; 47: 155-62 19) Goto S, Tamura N Ishida H. Ability of Anti-Glycoprotein IIb/IIIa Agents to Dissolve Plate Thrombi Formed on a Collagen Surface Under Blood Flow Conditions. Journal of the American College of Cardiology.2004, 44:316-23. 20) Hagihara M, Higuchi A, Tamura N, Ueda Y, Hirabayashi K, Ikeda Y, Kato S, Sakamoto S, Hotta T, Handa S and Goto S. Platelets, after Exposure to a High Shear Stress, Induce IL-10-Producing, Mature Dendritic Cells In Vitro, The Journal of Immunology, 2004, 172: 5297-5303. 21) Sadiq A, Tamura N, Yoshida M, Hoshiba Y, Kumagai A, Tanabe T, Handa S, Ikeda Y, Goto S. Possible contribution of acetylamrinone and its enhancing effects on platelet aggregation under shear stress conditions in the onset of thrombocytopenia in patients treated with amrinone. Thromb Research. 2003; 111(6): 357-61. 22) Goto S, Tamura N, Li M, Handa Y, Ikeda S, Handa S and Ruggeri ZM. Different effects of various anti-GPIIb-IIIa agents on shear –induced platelet activation and expression of procoagulant activity. Journal of Thrombosis and Haemostasis. 2003;1:2022-2030. 23) Tamura N, Yoshida Y, Ichikawa N, Handa M, Ikeda Y, Tanabe T, Handa S and Goto S. Shear-Induced von Willebrand factor platelet surface translocation of the CD 40 ligand. Thrombosis Research .2003; 108: 311-315. 24) Goto S, Tamura N, Handa S, Arai M, Kodama K, and Takayama H. Involvement of GPVI in Platelet Thrombus Formation on both Collagen and von Willebrand Factor Surfaces Under Flow Conditions. Circulation.2002; 106:266-272. 25) Sakakibara M, Goto S, Eto K, Tamura N, Isshiki T and Handa S. Application of Vivo Flow Chamber System for Assessment of Stent. Thrombosis. Arterioscler Thromb Vasc Biol.2002; 22: 1360-1364. 26) Goto S, Tamura N, and Handa S. Effects of adenosine 5'-diphosphate (ADP) receptor blockade on platelet aggregation under flow. Blood (letters.) 2002; 99:4644-4645. 27) Goto S, Tamura N, Eto K, Ikeda Y, and Handa S. Functional significance of adenosine 5-diphosphate receptor (P2Y12) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ib alpha induced by condition of high shear rate. Circulation. 2002; 105: 2531-2536. 28) Goto S, Tamura N, Sakakibara M, Ikeda Y, and Handa S. Effects of Ticlopidine on Von Willebrand Factor Mediated Shear-Induced Platelet Activation and Aggregation.:Platelets 12 (7) (2001) 406-414 29) Noriko Tamura, Hiroyuki Takahashi, Go Takeba, Takahide Satoi, and Hiroki Nakagawa. The nitrate reductase gene isolated from DNA of cultured spinach cells; Biochemica et Biophysica Acta 1338 (1997) 151-155