塚本徹雄 | | 新潟医療福祉大学

医療経営管理学部

Department of Health Informatics 医療情報管理学科

教員紹介

塚本徹雄写真

医療経営管理学部／医療情報管理学科
Faculty of Healthcare Management／Department of Health Informatics

塚本徹雄 Tetsuo Tsukamoto

教授

プロフィール

担当科目	人体の構造と機能、医療情報倫理学、医学概論(診療放射線学科)、内科学I・II(理学療法学科)
専門分野	微生物学、免疫学
学位・称号／取得機関／取得年	博士（医学）／東京大学／2008年
資格	医師
所属団体・学会等	日本分子生物学会、日本ウイルス学会、日本エイズ学会、American Society for Microbiology、Free Software Foundation

外部リンク

業績等

研究領域	ヒト免疫不全ウイルス(HIV)感染症の病態生理の解明、ストレス存在下での造血幹前駆細胞の動態の解明、マウスにおける赤白血病発症機構の解明
研究紹介	HIVに対するT細胞免疫応答の観察経験より、免疫系の設計(再帰性、並列性、キャッシュ機構)の理解を進めている。また、HIV感染における造血幹前駆細胞の動態を理解することにより、後天性免疫不全症候群(エイズ)のより良い定義を試みている。これまでにエイズワクチン開発(サルエイズモデル)、ウイルス特異的CD8陽性T細胞応答、抗HIV遺伝子治療(ヒト化マウスモデル)、造血幹前駆細胞動態に関する論文を出版している。
受賞歴	1. 2020 近畿大学医学会賞 2. 2019 近畿大学医学会賞
研究論文（英文）	1. Tetsuo Tsukamoto, Dean L. Winslow Predicting tuberculosis at antiretroviral therapy initiation: the combination of monocyte-to-lymphocyte ratio and hemoglobin level may be a key AIDS 2024 38 (1) 115-117 2. Alexander O. Pasternak, Tetsuo Tsukamoto, Ben Berkhout ‘Zombie’ proviruses in the spotlight: exploring the dark side of HIV persistence AIDS 2023 37 (14) 2239-2241

Profile

Research Areas	The immunopathogenesis of HIV/AIDS; Hematopoiesis
Research Introduction	Tetsuo Tsukamoto is a researcher looking for methods to better understand HIV's interaction with the host from the point of view of the immune system design. He has published studies on HIV vaccine development using rhesus macaques, HIV-specific CD8+ T-cell responses, anti-HIV gene therapy using humanized mice, and hematopoietic stem/progenitor cell dynamics in HIV infection.
Books	Tsukamoto T, Gorantla S, Rodrigues V. Direct and indirect interactions of HIV with host cells. Frontiers Media SA: 2021. Tsukamoto T. Gene therapy approaches to functional cure and protection of hematopoietic potential in HIV infection. In: Novel Approaches for the Delivery of Anti-HIV Drugs, MDPI: 2020; p5-22. Tsukamoto T, Matano T. AIDS. In: Clinical Mucosal Immunology (Japanese), Kiyono H (editor), Synergy International Inc.: 2010; p. 455–464.
Papers	1. 2023 Tetsuo Tsukamoto, Dean L. Winslow Predicting tuberculosis at antiretroviral therapy initiation: the combination of monocyte-to-lymphocyte ratio and hemoglobin level may be a key AIDS 2024 38 (1) 115-117 2. 2023 Alexander O. Pasternak, Tetsuo Tsukamoto, Ben Berkhout ‘Zombie’ proviruses in the spotlight: exploring the dark side of HIV persistence AIDS 2023 37 (14) 2239-2241 Tsukamoto T. HIV accelerates clonal hematopoiesis and cardiovascular aging. AIDS 36(11): 1599-1601, 2022. Tsukimoto S, Hakata Y, Tsuji-Kawahara S, Enya T, Tsukamoto T, Mizuno S, Takahashi S, Nakao S, Miyazawa M. Viruses 14(4): 832-832, 2022. Tsukamoto T. Advances in the development of CAR T cell-based anti-HIV therapies. Bio Clinica (Japanese) 2021; 36(12): 2016–2019. Tsukamoto T, Gorantla S, Rodrigues V. Editorial: Direct and indirect interactions of HIV with host cells. Front Cell Infect Microbiol 2021; 11: 771370. Tsukamoto T. Potential antibody-based strategies for HIV infection. Precision Medicine (Japanese) 2021; 4(1): 70–75. Tsukamoto T. HIV infection: hematological pathogenesis and potential future treatments. Precision Medicine (Japanese) 2020; 3(8): 771–776. Tsukamoto T, Nakamura K, Okada S. Simian immunodeficiency virus infection and flow cytometric characterization of Japanese macaque (Macaca fuscata) hematopoietic cells. J Med Primatol 2020; 49 (2): 116–120. doi: 10.1111/jmp.12460 Tsukamoto T. Hematopoietic stem/progenitor cells and the pathogenesis of HIV/AIDS. Front Cell Infect Microbiol 2020; 10: 60. doi: 10.3389/fcimb.2020.00060 Dunbar PR, Cartwright EK, Wein AN, Tsukamoto T, Li ZT, Kumar N, Uddbäck IE, Hayward SL, Ueha S, Takamura S, Kohlmeier JE. Pulmonary monocytes interact with effector T cells in the lung tissue to drive TRM differentiation following viral infection. Mucosal Immunol 2020; 13(1): 161–171. doi: 10.1038/s41385-019-0224-7 Tsukamoto T. Spontaneous HIV controllers might be the key to prevent accelerated immunosenescence of effector CD8+ T cells. AIDS, 2019; 33(14): 2253–2255. doi: 10.1097/QAD.0000000000002343 Tsukamoto T. Regenerative approaches to HIV disease. Bio Clinica (Japanese) 2019; 34(13): 1361–1366. Tsukamoto T, Tsuji-Kawahara S, Miyazawa M. The mechanisms for leukemogenesis in Friend virus-infected mice. Bio Clinica (Japanese) 2019; 34(6): 629–635. Tsukamoto T. Gene therapy approaches to functional cure and protection of hematopoietic potential in HIV infection. Pharmaceutics 2019; 11(3): 114. doi: 10.3390/pharmaceutics11030114 Tsukamoto T. HIV impacts CD34+ progenitors involved in T-cell differentiation during coculture with mouse stromal OP9-DL1 cells. Front Immunol 2019; 10: 81. doi: 10.3389/fimmu.2019.00081 Tsukamoto T, Yahamato H, Matano T. CD8+ cytotoxic-T-lymphocyte breadth could facilitate early immune detection of immunodeficiency virus-derived epitopes with limited expression levels. mSphere 2019; 4(1): e00381-18. doi: 10.1128/mSphere.00381-18 Tsukamoto T. Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34+ cells in HIV-1 infection. AIDS 2018; 32(13): 1737-1747. doi: 10.1097/QAD.0000000000001882 (Erratum in AIDS 2018; 32: 2857–2858) Tsukamoto T, Okada S. The use of RetroNectin in studies requiring in vitro HIV infection of human hematopoietic stem/progenitor cells. J Virol Methods 2017; 248: 234–237. doi: 10.1016/j.jviromet.2017.08.003 Tsukamoto T, Yamamoto H, Okada S, Matano T. Recursion-based depletion of human immunodeficiency virus-specific naive CD4+ T cells may facilitate persistent viral replication and chronic viraemia leading to acquired immunodeficiency syndrome. Med Hypotheses 2016; 94: 81–5. doi: 10.1016/j.mehy.2016.06.024 Tsukamoto T. A query by HIV. Chahier multiculturel de la Maison du Japon (Centre d’Études Multiculturelles de la Maison du Japon) 2013; 6: 3–11. ISSN 2111–4048 Nomura T, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T*. Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques. J Virol 2012; 86(12): 6481–90. Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T. Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques. J Virol 2012; 86(2): 738–45. Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T. Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge. Biochem Biophys Res Commun 2011; 408(4): 615–9. Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T. Broadening of CD8+ cell responses in vaccine-based simian immunodeficiency virus controllers. AIDS 2010; 24(18): 2777–87. Tsukamoto T, Matano T. Is the immune system able to protect itself? A query by HIV. Experimental Medicine (Japanese) 2009; 27: 1634–38. Tsukamoto T, Takeda A, Yamamoto T, Yamamoto H, Kawada M, Matano T. Impact of cytotoxic-T-lymphocyte memory induction without virus-specific CD4+ T-cell help on control of a simian immunodeficiency virus challenge in rhesus macaques. J Virol 2009; 83(18): 9339–46. Yamamoto T, Iwamoto N, Yamamoto H, Tsukamoto T, Kuwano T, Takeda A, Kawada M, Tsunetsugu-Yokota Y, Matano T. Polyfunctional CD4+ T-cell induction in neutralizing antibody-triggered control of simian immunodeficiency virus infection. J Virol 2009; 83(11): 5514–24. Takeda A, Igarashi H, Kawada M, Tsukamoto T, Yamamoto H, Inoue M, Iida A, Shu T, Hasegawa M, Matano T. Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques. Vaccine 2008; 26(52): 6839–43. Kawada M, Tsukamoto T, Yamamoto H, Iwamoto N, Kurihara K, Takeda A, Moriya C, Takeuchi H, Akari H, Matano T. Gag-specific cytotoxic T-lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial. J Virol 2008; 82(20): 10199–206. Tsukamoto T, Dohki S, Ueno T, Kawada M, Takeda A, Yasunami M, Naruse T, Kimura A, Takiguchi M, Matano T. Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope. AIDS 2008; 22(8): 993–4. Moriya C, Igarashi H, Takeda A, Tsukamoto T, Kawada M, Yamamoto H, Inoue M, Iida A, Shu T, Hasegawa M, Nagai Y, Matano T. Abrogation of AIDS vaccine-induced cytotoxic T-lymphocyte efficacy in vivo due to a change in viral epitope flanking sequences. Microbes Infect 2008; 10(3): 285–92. Tsukamoto T. Analysis of the ability of CD8+ cells to suppress immunodeficiency virus replication. Graduate School of Medicine, The University of Tokyo, 2008 (Thesis). Tsukamoto T, Yuasa M, Yamamoto H, Kawada M, Takeda A, Igarashi H, Matano T. Induction of CD8+ cells able to suppress CCR5-tropic simian immunodeficiency virus SIVmac239 replication by controlled infection of CXCR4-tropic simian-human immunodeficiency virus in vaccinated rhesus macaques. J Virol 2007; 81(21): 11640–9. Kawada M, Tsukamoto T, Yamamoto H, Takeda A, Igarashi H, Watkins DI, Matano T. Long-term control of simian immunodeficiency virus replication with central memory CD4+ T-cell preservation after nonsterile protection by a cytotoxic T-lymphocyte-based vaccine. J Virol 2007; 81(10): 5202–11. Yamamoto H, Kawada M, Tsukamoto T, Takeda A, Igarashi H, Miyazawa M, Naruse T, Yasunami M, Kimura A, Matano T. Vaccine-based, long-term, stable control of simian/human immunodeficiency virus 89.6PD replication in rhesus macaques. J Gen Virol 2007; 88: 652–9. Kawada M, Igarashi H, Takeda A, Tsukamoto T, Yamamoto H, Dohki S, Takiguchi M, Matano T. Involvement of multiple epitope-specific cytotoxic T-lymphocyte responses in vaccine-based control of simian immunodeficiency virus replication in rhesus macaques. J Virol 2006; 80(4): 1949–58. Tsukamoto T, Matano T. From possibility to conditional probability: immunological design for an AIDS vaccine. Antibiotics & Chemotherapy (Japanese) 2005; 21: 1141–1145.