特色
大学概要
学部・学科
キャンパスライフ
就職・資格
入試情報
特色
大学概要
学部・学科
キャンパスライフ
就職・資格
入試情報
リハビリテーション学部
Department of Physical Therapy 理学療法学科
リハビリテーション学部／理学療法学科
Faculty of Rehabilitation／Department of Physical Therapy
大鶴 直史 Naofumi Otsuru
教授
| 担当科目 | 理学療法基礎評価学Ⅱ、物理療法学、神経筋機能解析学、研究法 |
|---|---|
| 専門分野 | 神経科学、脳機能計測 |
| キーワード | 脳磁場計測、経頭蓋電流刺激、痛み、情動、内受容感覚 |
| 学位・称号／取得機関／取得年 | 博士（理学）／総合研究大学院大学／2010年 |
| 資格 | 理学療法士 |
| 過去の経歴 | 自然科学研究機構生理学研究所博士研究員、広島大学大学院医歯薬保健学研究院助教を経て現職 |
| 所属団体・学会等 | 日本理学療法士協会、日本臨床神経生理学会、日本生体磁気学会、北米神経科学学会、日本運動器疼痛学会、日本ペインリハビリテーション学会 |
| 研究領域 | 神経科学、痛みの脳内情報処理、慢性疼痛臨床研究 |
|---|---|
| 研究紹介 | リハビリテーションを必要とされる患者さんの多くが、からだに痛みを抱えておられます。その中には、治療が難しい痛みも含まれています。痛みに関連する脳活動を調べることによって、痛みがどのように生み出されるか、またどのようにすれば痛みを抑えられるかに関する研究をしています。 |
| 著書 | 1. 大鶴直史 リハビリテーション神経科学 痛みと神経心理 玉置 彰 Medical view 2019年3月 90-104 2. 大鶴直史 リハビリテーション神経科学 誘発脳磁界の基礎と応用 玉置 彰 Medical view 2019年3月 172-186 |
| 受賞歴 | 1. 2009 4th Asian and Oceanian Congress of Clinical Neurophysiology: Travel Award 2. 2010 29th International Congress of Clinical Neurophysiology: Young Investigator Award 3. 2011 第26回日本生体磁気学会：奨励賞（35歳以下） 4. 2017 計測自動制御学会：技術奨励賞 |
| 研究論文（英文） | 1. Hara M, Sugata H, Otsuru N, Takasaki M, Ishino Y, Mizuno T, Miki M, Kanayama N. Effect of a Body Part Action on Body Perception of the Other Inactive Body Part. IEEE Transactions on Cognitive and Developmental Systems 2022 1 2. Kitatani R, Furukawa K, Sakaue D, Otsuru N, Onishi H Influences of different cognitive loads on central common neural drives to the ankle muscles during dual-task walking Neurosci Lett 2022 804: 137214 3. Onishi H, Nagasaka K, Yokota H, Kojima S, Ohno K, Sakurai N, Kodama N, Sato D, Otsuru N Association between somatosensory sensitivity and regional gray matter volume in healthy young volunteers: a voxel-based morphometry study Cereb Cortex 2022 33: 2001-2010 4. Shiga K, Miyaguchi S, Inukai Y, Otsuru N, Onishi H Transcranial direct current stimulation over the right intraparietal sulcus improves response inhibition Behav Brain Res 2022 437: 114110 5. Shibata S, Watanabe T, Otsuru N, Onishi H, Mima T Very low-frequency transcranial electrical stimulation over the primary motor area can influence the voluntary movement initiation in humans Brain Stimul 2022 16: 794173 6. Yokota H, Edama M, Hirabayashi R, Sekine C, Otsuru N, Saito K, Kojima S, Miyaguchi S, Onishi H Effects of Stimulus Frequency, Intensity, and Sex on the Autonomic Response to Transcutaneous Vagus Nerve Stimulation Brain Sci 2022 12 7. Yoshino A, Otsuru N, Doi M, Maekawa T, Sasaoka T, Yamawaki S Interoceptive accuracy is related to the psychological mechanisms of the burning mouth syndrome: a cross-sectional study BMC Oral Health 2022 22: 297 8. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Nagasaka K, Onishi H Effect of Transcranial Electrical Stimulation over the Posterior Parietal Cortex on Tactile Spatial Discrimination Performance Neuroscience 2022 494: 94-103 9. Kawakami S, Inukai Y, Ikarashi H, Watanabe H, Miyaguchi S, Otsuru N, Onishi H Transcranial direct current stimulation and transcranial random noise stimulation over the cerebellum differentially affect the cerebellum and primary motor cortex pathway J Clin Neurosci 2022 100: 59-65 10. Van Pham M, Saito K, Miyaguchi S, Watanabe H, Ikarashi H, Nagasaka K, Yokota H, Kojima S, Inukai Y, Otsuru N, Onishi H Changes in excitability and GABAergic neuronal activity of the primary somatosensory cortex after motor learning Front Neurosci 2022 16: 74173 11. Miyaguchi S, Inukai Y, Hashimoto I, Otsuru N, Onishi H. Sleep affects the motor memory of basketball shooting skills in young amateurs. Journal of clinical neuroscience 2022 96: 187-193, 12. Nagasaka K, Otsuru N, Sato R, Watanabe H, Sakurai N, Ohno K, Kodama N, Onishi H. Cortical signature related to psychometric properties of pain vigilance in healthy individuals: A voxel-based morphometric study. Neuroscience letters 2022 772: 136445, 13. Kojima S, Miyaguchi S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability. Brain Sciences 2021 11: 1494, 14. Yoshino A, Otsuru N, Okada G, Tanaka K, Yokoyama S, Okamoto Y, Yamawaki S. Brain changes associated with impaired attention function in chronic pain. Brain and cognition 2021 154: 105806 15. Sakai S, Saito K, Kojima S, Otsuru N, Onishi H. Grating orientation task trial numbers for short- and long-term tactile discrimination learning. Journal of clinical neuroscience 2021 93: 195-199, 16. Watanabe H, Kojima S, Nagasaka K, Ohno K, Sakurai N, Kodama N, Otsuru N, Onishi H. Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype. Cerebral cortex, 2021 32: 2635-2643 17. Baba Y, Sato D, Otsuru N, Ikarashi K, Fujimoto T, Yamashiro K. Does Long-Term Training in a Water Immersion Environment Change Interoception? International journal of environmental research and public health 2021 18: 10259, 18. Hoshi H, Kojima S, Otsuru N, Onishi H. Effects of transcranial random noise stimulation timing on corticospinal excitability and motor function. Behavioural brain research 2021 414: 113479, 19. Sasaki R, Watanabe H, Miyaguchi S, Otsuru N, Ohno K, Sakurai N, Kodama N, Onishi H. Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance. Behavioural brain research 2021 412: 113433 20. Otsuru N, Ogawa M, Yokota H, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers. Eur J Pain, in press, 2021 26: 349-355 21. Ikarashi H, Otsuru N, Yokota H, Nagasaka K, Igarashi K, Miyaguchi S, Onishi H. Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. International journal of environmental research and public health 2021 18: 13625, 22. Kimura S, Hosoi M, Otsuru N, Iwasaki M, Matsubara T, Mizuno Y, Nishihara M, Murakami T, Yamazaki R, Ijiro H, Annno K, Watanabe K, Kitamura T, Shouhei Y. A novel exercise facilitation method in combination with cognitive behavioral therapy using ikiiki rehabilitation notebook for intractable chronic pain: Technical report and 22 cases. Healthcare 2021 9: 1209, 23. Kojima S, Otsuru N, Miyaguchi S, Yokota H, Nagasaka K, Saito K, Inukai Y, Shirozu H, Onishi H. The intervention of mechanical tactile stimulation modulates somatosensory evoked magnetic fields and cortical oscillations. European Jo 2021 53: 3433-3446 24. Sasaki R, Otsuru N, Miyaguchi S, Kojima S, Watanabe H, Ohno K, Sakurai N, Kodama N, Sato D, Onishi H. Influence of brain-derived neurotropic factor genotype on short-latency afferent inhibition and motor cortex metabolites. Brain Sciences 2021 11, 395, 25. Saito K, Otsuru N, Yokota H, Inulai Y, Miyaguchi S, Kojima S, Onishi H. Alpha-tACS over the somatosensory cortex enhances tactile spatial discrimination in healthy subjects with low alpha activity. Brain and Behavior 2021 11, e02019, 26. Yamashiro K, Yamazaki Y, Siiya K, Ikarashi K, Baba Y, Otsuru N, Onishi H, Sato D. Modality-specific improvements in sensory processing among baseball players. Scientific Reports 2021 11, 2248, 27. Hoshi H, Kojima S, Otsuru N, Onishi H. Corticospinal excitability of untrained side depends on the type of motor task and degree of improvement in motor function. Brain and Cognition 2021 148, 105691, 28. Inukai Y, Miyaguchi S, Kobayashi N, Otsuru N, Onishi H. Noisy galvanic vestibular stimulation effect on center of pressure sway during one-legged standing. Journal of Clinical Neuroscience 2020 82, 173-178, 29. Pham Van M, Miyaguchi S, Watanabe H, Saito K, Otsuru N, Onishi H. Effect of repetitive passive movement before motor skill training on corticospinal excitability and motor learning depend on BDNF polymorphisms. Frontiers in Human Neuroscience, 2020 in press. 30. Yokota H, Otsuru N, Saito K, Kojima S, Miyaguchi S, Inukai Y, Nagasaka K, Onishi H. Region-specific effects of 10-Hz transcranial alternate current stimulation over the left posterior parietal cortex and primay somatosensory area on the tactile two-point discrimination threshold. Frontiers in Neuroscience, 2020 in press. 31. Inukai Y, Miyaguchi S, Satio M, Otsuru N, Onishi H. Effects of different stimulation conditions on the stimulation effect of noisy galvanic vestibular stimulation. Frontiers in Human Neurosicence 2020 14, 581405, 32. Miyaguchi S, Inukai Y, Takahashi R, Miyashita M, Matsumoto Y, Otsuru N, Onishi H. Effetcs of stimulating the supplementary motor area with a transcranial alternating current for bimanual movement performance. Behavioural Brain Research 2020 393, 112801, 33. Miyaguchi S, Inukai Y, Matsumoto Y, Miyashita M, Takahashi R, Otsuru N, Onishi H. Effects on motor learning of transcranial alternating current stimulation applied over the primary motor cortex and cerebellar hemisphere. Journal of Clinical Neuroscience 2020 78, 296-300, 34. Otsuru N, Miyaguchi S, Kojima S, Yamashiro K, Sato D, Yokota H, Saito K, Inukai Y, Onishi H. Timing of modulation of corticospinal excitability by heartbeat differs with interoceptive accuracy. Neuroscience 2020 433, 156-162, 35. Inukai Y, Otsuru N, Saito K, Kojima S, Nagasaka K, Yokota H, Miyaguchi S, Onishi H. The after effect of galvanic vestibular stimulation on postural control in young people: a randomized controlled trial. Neuroscience Letters 2020, 729, 135009, 36. Watanabe H, Kojima S, Otsuru N, Onishi H. The repetitive mechanical tactile stimulus intervention effects depend on input methods. Frontiers in Neuroscience 2020 14, 393, 37. Yamazaki Y, Yamashiro K, Onishi H, Otsuru N, Kojima S, Saito K, Sato D. Modulation of inhibitory function in the primary somatosensory cortex and temporal discrimination threshold induced by acute aerobic exercise. Behavioural Brain Research 2020 377, 112253, 38. Kojima S, Miyaguchi S, Sasaki R, Tsuiki S, Saito K, Inukai Y, Otsuru N, Onishi H. The effects of mechanical tactile stimulation on corticospinal excitability and motor function depend on pin protrusion patterns. Scientific Reports 2019 9, 16677, 39. Otsuru N, Kamijo K, Otsuki T, Kojima S, Miyaguchi S, Saito K, Inukai Y, Onishi H. 10 Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment, Behavioural Brain Research 2019 368, 111899, 40. Yamashiro K, Sato D, Onishi H, Sugawara K, Otsuru N, Kirimoto H, Nakazawa S, Yamazaki Y, Shirozu H, Maruyama A. Change-driven M100 component in the bilateral secondary somatosensory cortex: A magnetoencephalographic study. Brain topography 2019 32, 435-444, 41. Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H. Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behavioural Brain Research 2019 375, 112168, 42. Yokota H, Otsuru N, Kikuchi R, Suzuki R, Kojima S, Saito K, Miyaguchi S, Inukai Y, Onishi H. Establishment of optimal two-point discrimination test method and consideration of reproducibility. Neuroscience Letters 2020 714, 134525, 43. Miyaguchi S, Yamaguchi M, Kojima S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. Time course of bilateral corticospinal tract excitability in the motor-learning process. Neuroscience letters 2019 771: 134410, 44. Abe T, Miyaguchi S, Otsuru N, Onishi H. The effect of transcranial random noise stimulation on corticospinal excitability and motor performance. Neuroscience Letter 2019 705: 138-142, 45. Tsuiki S, Sasaki R, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability. PLOS One 2019 14, e0214592, 46. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. The effect of gamma tACS over the M1 region and cerebellar hemisphere does not depend on current intensity. Journal of Clinical Neuroscience, 2019 65, 54-58, 47. Tsuiki S, Sasaki R, Pham Van Manh, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive passive movement modulates corticospinal excitability: Effect of movement and rest cycles and subject attention. Frontiers in Behavioral Neuroscience, 2019, in press 48. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner. Neurosci Lett 2019 694: 64-68, 49. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Somatosensory inputs induced by passive movement facilitate primary motor cortex excitability depending on the interstimulus interval, movement velocity, and joint angle. Neuroscience 2018 386: 194-204, 50. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive passive finger movement modulates primary somatosensory cortex excitability. Frontiers in Human Neuroscience 2018 12: 332 51. Inukai Y, Masaki M, Otsuru N, Saito K, Miyaguchi S, Kojima S, Onishi H. The effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomized controlled trial. Journal of NeuroEngineering and Rehabilitation 2018 3: 15 52. Miyaguchi S, Otsuru N, Kojima S, Saito K, Inukai Y, Masaki M, Onishi H. Transcranial alternating current stimulation with gamma oscillations over the primary motor cortex and cerebellar hemisphere improved visuomotor performance. Frontiers in Behavioral Neuroscience 2018 12: 132. 53. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Tsuiki S, Sasaki R, Onishi H. Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination. Neuroscience 2018 384: 262-274. 54. Onishi H, Otsuru N, Kojima S, Miyaguchi S, Saito K, Inukai Y, Yamashiro K, Sato D, Tamaki H, Shirozu H, Kameyama S. Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation. Brain topography 2018 31: 780-794. 55. Inukai Y, Otsuru N, Masaki M, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation on center of pressure sway of static standing posture. Brain Stimulation 2017 11: 85-93. 56. Yoshino A, Okamoto Y, Doi M, Otsuru N, Okada G, Takamura M, Ichikawa N, Yokoyama S, Yamashita H, Yamawaki S. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain. Scientific Reports 2017 7: 30003. 57. Kirimoto H, Tamaki H, Otsuru N, Yamashiro K, Onishi H, Nojima I, Oliviero A. Transcranial static magnetic field stimulation over the primary motor cortex induces plastic changes in cortical nociceptive processing. Frontiers Human Neuroscience 2018 12: 63 58. Sasaki R, Nakagawa M, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H: Regulation of primary motor cortex excitability by repetitive passive finger movement frequency. Neuroscience 2017 357: 232-240, 59. Imura T, Tomiyasu M, Otsuru N, Nakagawa K, Otsuka T, Takahasi S, Takeda M, Shrestha L, Kawahara Y, Fukazawa T, Sueda T, Tanimoto K, Yuge L: Hypoxic preconditioning increases the neuroprotective effects of mesenchymal stem cells in a rat model of spinal cord injury. J Stem Cell Res Ther 2017 7: 375, 60. Inukai Y, Saito K, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Masaki M, Otsuru N, Onishi H: Comparison of three non-invasive transcranial electrical stimulation methods for increasing cortical excitability. Front Hum Neurosci 2016 10: 668, 61. Yoshino A, Okamoto Y, Doi M, Horikoshi M, Oshita K, Nakamura R, Otsuru N, Yoshimura S, Tanaka K, Takagaki K, Jinnin R, Yamashita H, Kawamoto M, Yamawaki S: Effectiveness of group cognitive behavioral therapy (GCBT) for somatoform pain disorder patients in Japan: A preliminary non-case-control study. Psychiat Clin Neurosci 2015 69: 763-772, 62. Nishihara M, Inui K, Morita T, Kodaira M, Mochizuki H, Otsuru N, Motomura E, Ushida T, Kakigi R: Echoic memory: Investigation of its temporal resolution analyzed by auditory offset cortical responses. PLOS ONE 2014 9: e106553, 63. Otsuru N, Hashizume A, Nakamura D, Endo Y, Inui K, Kakigi R, Yuge L: Sensory incongruence leading to hand disownership modulates somatosensory cortical processing. Cortex 2014 58:1-8, 64. Nakagawa K, Otsuru N, Inui K, Kakigi R: Change-related auditory P50: A MEG study. NeuroImage 2014 86:131 -137, 65. Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R: Somatotopic representation of pain in the primary somatosensory cortex (SI) in humans. Clin Neurophysiol 2013 124:1422-1430, 66. Otsuru N, Tsuruhara A, Motomura E, Tanii H, Nishihara M, Inui K, Kakigi R: Effects of acute nicotine on auditory change-related cortical responses. Psychopharmacology 2012 224:327-335, 67. Ohoyama K, Motomura E, Inui K, Nishihara M, Otsuru N, Oi M, Kakigi R, Okada M: Memory-based pre-attentive auditory N1 elicited by sound movement. Neurosci Res 2012 73:248-251, 68. Keceli S, Inui K, Okamoto H, Otsuru N, Kakigi R: Auditory sustained field responses to periodic noise. BMC Neurosci 2012 13: 7, 69. Yamashiro K, Inui K, Otsuru N, Urakawa T, Kakigi R: Temporal window of integration in the somatosensory modality: An MEG study. Clin Neurophysiol 2011 122:2276-2281, 70. Nishihara M, Inui K, Motomura E, Otsuru N, Ushida T, Kakigi R: Auditory N1 as a change-related automatic response. Neurosci Res 2011 71:145-148, 71. Otsuru N, Inui K, Yamashiro K, Urakawa T, Keceli S, Kakigi R: Effects of prior sustained tactile stimulation on the somatosensory response to the sudden change of intensity in humans: an magnetoencephalography study. Neuroscience 2011 182:115 -124, 72. Inui K, Urakawa T, Yamashiro K, Otsuru N, Takeshima Y, Nishihara M, Motomura E, Kida T, Kakigi R: Echoic memory of a single pure tone indexed by change-related brain activity. BMC Neurosci 2010 11:135, 73. Inui K, Urakawa T, Yamashiro K, Otsuru N, Nishihara M, Takeshima Y, Keceli S, Kakigi R: Non-linear laws of echoic memory and auditory change detection in humans. BMC Neurosci 2010 11: 80, 74. Yamashiro K, Inui K, Otsuru N, Kakigi R: Change-related response in the human auditory cortex: An MEG study. Psychophysiology 2010 48:23-30, 75. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Takeshima Y, Kakigi R: Assessing A-delta fiber function with lidocaine using intra-epidermal electrical stimulation. J Pain 2010 11:621-627, 76. Mochizuki H, Inui K, Tanabe HC, Akiyama LF, Otsuru N, Yamashiro K, Sasaki A, Nakata H, Sadato N, Kakigi R: Time course of activity in itch-related brain regions: A combined MEG-fMRI study. J Neurophysiol 2009 102:2657-2666, 77. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Ohsawa I, Takeshima Y, Kakigi R: Selective stimulation of C fibers by an Intra-epidermal needle electrode in humans. The Open Pain Journal 2009 2:53-56, 78. Yamashiro K, Inui K, Otsuru N, Kida T, Kakigi R: Automatic auditory off-response in humans: an MEG study. European Journal of Neuroscience 2009 30:125-131, 79. Yamashiro K, Inui K, Otsuru N, Kida T, Kakigi R: Somatosensory off response in humans: an MEG study. NeuroImage 2009 44:1363-1368, 80. Yamashiro K, Inui K, Otsuru N, Kida T, Akatsuka K, Kakigi R: Somatosensory off response in humans: an ERP study. Exp Brain Res 2008 190:207-213, 81. Mochizuki H, Inui K, Yamashiro K, Otsuru N, Kakigi R: Itching-related somatosensory evoked potentials. Pain 2008 138:598-603, |
| 報告書 | 1. |
| 科学研究費 | 1. 2011年～2014年 若手研究 舌痛症を画像診断する～脳機能画像を用いて 2. 2012年～2014年 4,160千円 若手研究 知覚―運動ループの不一致が痛覚および変化検出機構に及ぼす影響 3. 2015年～2017年 3,770千円 若手研究 自己身体認知の変化を誘発するリハビリテーション戦略の開発 4. 2018年～2020年 6,240千円 挑戦的研究（萌芽） バーチャルリアリティとロボティクスを応用した心拍駆動型身体認知変容システムの開発 5. 2019年～2021年 17,030千円 基盤研究（B） 慢性疼痛に対する認知行動療法の効果を向上させる脳内ネットワーク刺激戦略 6. 2020年～2022年 挑戦的研究（萌芽） 新しいニューロリハビリテーションを可能にするMEG対応ハプティック技術の創成 7. 2021年～2022年 挑戦的研究（萌芽） 内受容感覚のリアルタイムフィードバックによる新たな運動学習システムの開発 8. 2021年～2024年 基盤研究（B） 情動触に影響する生理・神経科学的個人差の検討 9. 2021年～2024年 基盤研究（B） 脳内ネットワークモジュールの相互作用を標的とした新たな神経リハビリテーション戦略 10. 2022年～2024年 6,240千円 挑戦的研究（萌芽） 不安定状態の脳内ネットワーク操作による恐怖記憶消去への挑戦 11. 2022年～2024年 挑戦的研究（萌芽） 慢性疼痛に対する簡易型オンライン集団CBTの開発ならびに治療同盟に関する検証 12. 2022年～2025年 挑戦的研究（開拓） 運動感覚改変による着身体・脱身体現象の誘発とリハビリ応用 13. 2022年～2024年 基盤研究（B） Realizing Human Brain Stimulation of Deep Regions Based on Novel Personalized Electrical Computational Modelling 14. 2022年～2025年 17,160千円 基盤研究（B） 慢性疼痛における治療非反応性の神経基盤解明による治療効果向上戦略 15. 2022年～2025年 基盤研究（A） 内受容感覚を利用した身体感覚の自然な“脱着” |
| 学会等研究発表 | 1. 鈴木孝昇，長坂和明，大槻智史，大鶴直史，大西秀明 The effects of tonic locus coeruleus output on forepaw-evoked response of the primary somatosensory cortex in anesthetized rats―麻酔下ラットにおける一次体性感覚野の前肢刺激誘発応答に青斑核の持続的刺激がおよぼす影響― NEURO 2022 2022/6/30-7/3 2. 高橋ひろな，犬飼康人，宮口翔太，大鶴直史，大西秀明 前庭ノイズ電流刺激がファンクショナルリーチテストに与える影響 第28回脳機能とリハビリテーション研究会学術集会 2022/9/1-9/23 3. 鈴木孝昇, 長坂和明，大槻智史，大鶴直史，大西秀明 1.0Hzのラット青斑核電気刺激は一次体性感覚野の活動を増大させる 第28回脳機能とリハビリテーション研究会学術集会 2022/9/1-9/23 4. 志賀恭介，宮口翔太，犬飼康人，大鶴直史，大西秀明 右頭頂間溝への経頭蓋直流電気刺激が反応抑制機能に与える影響 第28回脳機能とリハビリテーション研究会学術集会 2022/9/1-9/23 5. 五十嵐眸実，大鶴直史，長坂和明，宮口翔太，Jose Gomez-Tames，平田晃正，大西秀明 電界シミュレーションを用いた経頭蓋交流電流による鎮痛効果の検討 第28回脳機能とリハビリテーション研究会学術集会 2022/9/1-9/23 6. 川上紗輝，犬飼康人，五十嵐眸実，神居寧， 宮口翔太，大鶴直史，大西秀明 小脳への経頭蓋ランダムノイズ刺激による脳活動と運動学習の関連性 第28回脳機能とリハビリテーション研究会学術集会 2022/9/1-9/23 7. 齊藤慧，大鶴直史，小池康太郎，竹内皓太，大西秀明 背外側前頭前野への経頭蓋ランダムノイズ刺激が触覚方位弁別能力にもたらす効果 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 8. 五十嵐眸実，大鶴直史，長坂和明，宮口翔太，Jose Gomez-Tames，平田晃正，大西秀明 背外側前頭前野に対する経頭蓋交流電流刺激による鎮痛効果-電界シミュレーションによる検討- 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 9. 川上紗輝，犬飼康人，五十嵐眸実，神居寧，宮口翔太，大鶴直史，大西秀明 小脳への経頭蓋ランダムノイズ刺激が運動学習および脳活動に及ぼす影響 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 10. 横田裕丈，江玉睦明，平林怜，関根千恵，大鶴直史，齊藤慧，小島翔，宮口翔太，大西秀明 異なる電流強度による経皮的迷走神経刺激が自律神経活動に及ぼす影響 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 11. 三木陽菜乃，齊藤慧，平賀大河，宮口翔太，大鶴直史，大西秀明 脳由来神経栄養因子が末梢電気刺激の刺激効果にもたらす影響~方位弁別課題を用いた検証~ 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 12. 鈴木孝昇，長坂和明，大槻智史，大鶴直史，大西秀明 ラット青斑核への電気刺激が一次体性感覚野の神経活動へ与える影響 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 13. 北谷亮輔，本田快和，犬飼康人，大鶴直史，大西秀明 バランスディスク上での左プリズム適応が立位重心の左右変位に与える影響 第27回日本基礎理学療法学会学術大会 2022/10/1-10/2 |
| 学会・職能団体の委員 | 1. Frontiers in human neuroscience誌 review editor 2. Frontiers in Physiology誌 review editor 3. Frontiers in Pain Research誌 review editor 4. 日本生体磁気学会 理事 5. 日本ペインリハビリテーション学会 代議員 6. 日本運動器疼痛学会 代議員 7. 日本理学療法士協会「理学療法学」 査読委員 8. 全国大学理学療法学教育学会 庶務 9. 広島大学人間拡張実装プロジェクト研究センター 連携メンバー |
| 公的機関（官公庁等）の審議会・委員会等の委員 | 1. 2022 厚労省新潟県慢性疼痛診療モデル事業ワーキンググループ 委員 |
| 公開講座・講演会等 | 1. 2022 厚生労働省慢性疼痛体制構築モデル事業 新潟県慢性疼痛診療研修会 痛みの多面的評価（ICD-11を含む）を知ろう 講師 新潟大学 医師，PT，他コメディカルスタッフ オンライン 2022.7.31 2. 第20回日本神経理学療法学会学術大会 中枢性疼痛の脳内メカニズムとリハビリテーション オーガナイザー 日本神経理学療法学会 PT 大阪市 2022.10.15 3. 第6回日本リハビリテーション医学会秋季学術大会 運動器慢性疼痛に対するリハビリテーション医療の問題点と今後の展望 講師 日本リハビリテーション医学会 医師，PT，他コメディカルスタッフ 岡山市 2022.11.4 4. 第15回日本運動器疼痛学会 いきいきリハビリノート講習会 講師 日本運動器疼痛学会 医師，PT，他コメディカルスタッフ 栃木県 2022.11.19 5. 日本物理療法合同学術大会2023 疼痛の評価と治療 講師 一般社団法人 日本物理療法学会 医療従事者 東京都 2023.2.18-19 6. 日本ペインクリニック学会第3回北関東・甲信越支部学術集会 疼痛治療と多職種連携 講師 日本ペインクリニック学会 医療従事者 千葉市 2023.2.25 7. |
| その他の社会活動への参加協力 | 1. |
| 学内委員会活動 | 1. 科研費対策委員会（委員長） 2. 運動機能医科学研究所（副所長） 3. 次世代デジタルリハビリテーション研究センター（センター長） 4. 利益相反マネジメント委員会（委員） 5. 知的財産委員会（委員） |
| Research Areas | Pain processing in the brain |
|---|---|
| Research Introduction | Chronic pain is a major public health issue that is difficult to treat and decreases the quality of life. We aim to elucidate the pathophysiology of chronic pain by measuring brain activities and assessing interoception. We are also investigating the effectiveness of cognitive-behavioral therapy for chronic pain. |
| Books | Otsuru N. Pain and neuropsychology. Neuroscience for rehabilitation. 90-101. Tokyo: Medical View, 2019. Otsuru N. Fundamentals and Applications of evoked magnetic field of the human brain. Neuroscience for rehabilitation. 172-184. Tokyo: Medical View, 2019. |
| Papers | 1. 2022 Hara M, Sugata H, Otsuru N, Takasaki M, Ishino Y, Mizuno T, Miki M, Kanayama N. Effect of a Body Part Action on Body Perception of the Other Inactive Body Part. IEEE Transactions on Cognitive and Developmental Systems 2022 1 2. 2022 Kitatani R, Furukawa K, Sakaue D, Otsuru N, Onishi H Influences of different cognitive loads on central common neural drives to the ankle muscles during dual-task walking Neurosci Lett 2022 804: 137214 3. 2022 Onishi H, Nagasaka K, Yokota H, Kojima S, Ohno K, Sakurai N, Kodama N, Sato D, Otsuru N Association between somatosensory sensitivity and regional gray matter volume in healthy young volunteers: a voxel-based morphometry study Cereb Cortex 2022 33: 2001-2010 4. 2022 Shiga K, Miyaguchi S, Inukai Y, Otsuru N, Onishi H Transcranial direct current stimulation over the right intraparietal sulcus improves response inhibition Behav Brain Res 2022 437: 114110 5. 2022 Shibata S, Watanabe T, Otsuru N, Onishi H, Mima T Very low-frequency transcranial electrical stimulation over the primary motor area can influence the voluntary movement initiation in humans Brain Stimul 2022 16: 794173 6. 2022 Yokota H, Edama M, Hirabayashi R, Sekine C, Otsuru N, Saito K, Kojima S, Miyaguchi S, Onishi H Effects of Stimulus Frequency, Intensity, and Sex on the Autonomic Response to Transcutaneous Vagus Nerve Stimulation Brain Sci 2022 12 7. 2022 Yoshino A, Otsuru N, Doi M, Maekawa T, Sasaoka T, Yamawaki S Interoceptive accuracy is related to the psychological mechanisms of the burning mouth syndrome: a cross-sectional study BMC Oral Health 2022 22: 297 8. 2022 Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Nagasaka K, Onishi H Effect of Transcranial Electrical Stimulation over the Posterior Parietal Cortex on Tactile Spatial Discrimination Performance Neuroscience 2022 494: 94-103 9. 2022 Kawakami S, Inukai Y, Ikarashi H, Watanabe H, Miyaguchi S, Otsuru N, Onishi H Transcranial direct current stimulation and transcranial random noise stimulation over the cerebellum differentially affect the cerebellum and primary motor cortex pathway J Clin Neurosci 2022 100: 59-65 10. 2022 Van Pham M, Saito K, Miyaguchi S, Watanabe H, Ikarashi H, Nagasaka K, Yokota H, Kojima S, Inukai Y, Otsuru N, Onishi H Changes in excitability and GABAergic neuronal activity of the primary somatosensory cortex after motor learning Front Neurosci 2022 16: 74173 11. Miyaguchi S, Inukai Y, Hashimoto I, Otsuru N, Onishi H. Sleep affects the motor memory of basketball shooting skills in young amateurs. Journal of clinical neuroscience 2022 96: 187-193, 12. Nagasaka K, Otsuru N, Sato R, Watanabe H, Sakurai N, Ohno K, Kodama N, Onishi H. Cortical signature related to psychometric properties of pain vigilance in healthy individuals: A voxel-based morphometric study. Neuroscience letters 2022 772: 136445, 13. Kojima S, Miyaguchi S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability. Brain Sciences 2021 11: 1494, 14. Yoshino A, Otsuru N, Okada G, Tanaka K, Yokoyama S, Okamoto Y, Yamawaki S. Brain changes associated with impaired attention function in chronic pain. Brain and cognition 2021 154: 105806 15. Sakai S, Saito K, Kojima S, Otsuru N, Onishi H. Grating orientation task trial numbers for short- and long-term tactile discrimination learning. Journal of clinical neuroscience 2021 93: 195-199, 16. Watanabe H, Kojima S, Nagasaka K, Ohno K, Sakurai N, Kodama N, Otsuru N, Onishi H. Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype. Cerebral cortex, 2021 32: 2635-2643 17. Baba Y, Sato D, Otsuru N, Ikarashi K, Fujimoto T, Yamashiro K. Does Long-Term Training in a Water Immersion Environment Change Interoception? International journal of environmental research and public health 2021 18: 10259, 18. Hoshi H, Kojima S, Otsuru N, Onishi H. Effects of transcranial random noise stimulation timing on corticospinal excitability and motor function. Behavioural brain research 2021 414: 113479, 19. Sasaki R, Watanabe H, Miyaguchi S, Otsuru N, Ohno K, Sakurai N, Kodama N, Onishi H. Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance. Behavioural brain research 2021 412: 113433 20. Otsuru N, Ogawa M, Yokota H, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers. Eur J Pain, in press, 2021 26: 349-355 21. Ikarashi H, Otsuru N, Yokota H, Nagasaka K, Igarashi K, Miyaguchi S, Onishi H. Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. International journal of environmental research and public health 2021 18: 13625, 22. Kimura S, Hosoi M, Otsuru N, Iwasaki M, Matsubara T, Mizuno Y, Nishihara M, Murakami T, Yamazaki R, Ijiro H, Annno K, Watanabe K, Kitamura T, Shouhei Y. A novel exercise facilitation method in combination with cognitive behavioral therapy using ikiiki rehabilitation notebook for intractable chronic pain: Technical report and 22 cases. Healthcare 2021 9: 1209, 23. Kojima S, Otsuru N, Miyaguchi S, Yokota H, Nagasaka K, Saito K, Inukai Y, Shirozu H, Onishi H. The intervention of mechanical tactile stimulation modulates somatosensory evoked magnetic fields and cortical oscillations. European Jo 2021 53: 3433-3446 24. Sasaki R, Otsuru N, Miyaguchi S, Kojima S, Watanabe H, Ohno K, Sakurai N, Kodama N, Sato D, Onishi H. Influence of brain-derived neurotropic factor genotype on short-latency afferent inhibition and motor cortex metabolites. Brain Sciences 2021 11, 395, 25. Saito K, Otsuru N, Yokota H, Inulai Y, Miyaguchi S, Kojima S, Onishi H. Alpha-tACS over the somatosensory cortex enhances tactile spatial discrimination in healthy subjects with low alpha activity. Brain and Behavior 2021 11, e02019, 26. Yamashiro K, Yamazaki Y, Siiya K, Ikarashi K, Baba Y, Otsuru N, Onishi H, Sato D. Modality-specific improvements in sensory processing among baseball players. Scientific Reports 2021 11, 2248, 27. Hoshi H, Kojima S, Otsuru N, Onishi H. Corticospinal excitability of untrained side depends on the type of motor task and degree of improvement in motor function. Brain and Cognition 2021 148, 105691, 28. Inukai Y, Miyaguchi S, Kobayashi N, Otsuru N, Onishi H. Noisy galvanic vestibular stimulation effect on center of pressure sway during one-legged standing. Journal of Clinical Neuroscience 2020 82, 173-178, 29. Pham Van M, Miyaguchi S, Watanabe H, Saito K, Otsuru N, Onishi H. Effect of repetitive passive movement before motor skill training on corticospinal excitability and motor learning depend on BDNF polymorphisms. Frontiers in Human Neuroscience, 2020 in press. 30. Yokota H, Otsuru N, Saito K, Kojima S, Miyaguchi S, Inukai Y, Nagasaka K, Onishi H. Region-specific effects of 10-Hz transcranial alternate current stimulation over the left posterior parietal cortex and primay somatosensory area on the tactile two-point discrimination threshold. Frontiers in Neuroscience, 2020 in press. 31. Inukai Y, Miyaguchi S, Satio M, Otsuru N, Onishi H. Effects of different stimulation conditions on the stimulation effect of noisy galvanic vestibular stimulation. Frontiers in Human Neurosicence 2020 14, 581405, 32. Miyaguchi S, Inukai Y, Takahashi R, Miyashita M, Matsumoto Y, Otsuru N, Onishi H. Effetcs of stimulating the supplementary motor area with a transcranial alternating current for bimanual movement performance. Behavioural Brain Research 2020 393, 112801, 33. Miyaguchi S, Inukai Y, Matsumoto Y, Miyashita M, Takahashi R, Otsuru N, Onishi H. Effects on motor learning of transcranial alternating current stimulation applied over the primary motor cortex and cerebellar hemisphere. Journal of Clinical Neuroscience 2020 78, 296-300, 34. Otsuru N, Miyaguchi S, Kojima S, Yamashiro K, Sato D, Yokota H, Saito K, Inukai Y, Onishi H. Timing of modulation of corticospinal excitability by heartbeat differs with interoceptive accuracy. Neuroscience 2020 433, 156-162, 35. Inukai Y, Otsuru N, Saito K, Kojima S, Nagasaka K, Yokota H, Miyaguchi S, Onishi H. The after effect of galvanic vestibular stimulation on postural control in young people: a randomized controlled trial. Neuroscience Letters 2020, 729, 135009, 36. Watanabe H, Kojima S, Otsuru N, Onishi H. The repetitive mechanical tactile stimulus intervention effects depend on input methods. Frontiers in Neuroscience 2020 14, 393, 37. Yamazaki Y, Yamashiro K, Onishi H, Otsuru N, Kojima S, Saito K, Sato D. Modulation of inhibitory function in the primary somatosensory cortex and temporal discrimination threshold induced by acute aerobic exercise. Behavioural Brain Research 2020 377, 112253, 38. Kojima S, Miyaguchi S, Sasaki R, Tsuiki S, Saito K, Inukai Y, Otsuru N, Onishi H. The effects of mechanical tactile stimulation on corticospinal excitability and motor function depend on pin protrusion patterns. Scientific Reports 2019 9, 16677, 39. Otsuru N, Kamijo K, Otsuki T, Kojima S, Miyaguchi S, Saito K, Inukai Y, Onishi H. 10 Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment, Behavioural Brain Research 2019 368, 111899, 40. Yamashiro K, Sato D, Onishi H, Sugawara K, Otsuru N, Kirimoto H, Nakazawa S, Yamazaki Y, Shirozu H, Maruyama A. Change-driven M100 component in the bilateral secondary somatosensory cortex: A magnetoencephalographic study. Brain topography 2019 32, 435-444, 41. Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H. Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behavioural Brain Research 2019 375, 112168, 42. Yokota H, Otsuru N, Kikuchi R, Suzuki R, Kojima S, Saito K, Miyaguchi S, Inukai Y, Onishi H. Establishment of optimal two-point discrimination test method and consideration of reproducibility. Neuroscience Letters 2020 714, 134525, 43. Miyaguchi S, Yamaguchi M, Kojima S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. Time course of bilateral corticospinal tract excitability in the motor-learning process. Neuroscience letters 2019 771: 134410, 44. Abe T, Miyaguchi S, Otsuru N, Onishi H. The effect of transcranial random noise stimulation on corticospinal excitability and motor performance. Neuroscience Letter 2019 705: 138-142, 45. Tsuiki S, Sasaki R, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability. PLOS One 2019 14, e0214592, 46. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. The effect of gamma tACS over the M1 region and cerebellar hemisphere does not depend on current intensity. Journal of Clinical Neuroscience, 2019 65, 54-58, 47. Tsuiki S, Sasaki R, Pham Van Manh, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive passive movement modulates corticospinal excitability: Effect of movement and rest cycles and subject attention. Frontiers in Behavioral Neuroscience, 2019, in press 48. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner. Neurosci Lett 2019 694: 64-68, 49. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Somatosensory inputs induced by passive movement facilitate primary motor cortex excitability depending on the interstimulus interval, movement velocity, and joint angle. Neuroscience 2018 386: 194-204, 50. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive passive finger movement modulates primary somatosensory cortex excitability. Frontiers in Human Neuroscience 2018 12: 332 51. Inukai Y, Masaki M, Otsuru N, Saito K, Miyaguchi S, Kojima S, Onishi H. The effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomized controlled trial. Journal of NeuroEngineering and Rehabilitation 2018 3: 15 52. Miyaguchi S, Otsuru N, Kojima S, Saito K, Inukai Y, Masaki M, Onishi H. Transcranial alternating current stimulation with gamma oscillations over the primary motor cortex and cerebellar hemisphere improved visuomotor performance. Frontiers in Behavioral Neuroscience 2018 12: 132. 53. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Tsuiki S, Sasaki R, Onishi H. Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination. Neuroscience 2018 384: 262-274. 54. Onishi H, Otsuru N, Kojima S, Miyaguchi S, Saito K, Inukai Y, Yamashiro K, Sato D, Tamaki H, Shirozu H, Kameyama S. Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation. Brain topography 2018 31: 780-794. 55. Inukai Y, Otsuru N, Masaki M, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation on center of pressure sway of static standing posture. Brain Stimulation 2017 11: 85-93. 56. Yoshino A, Okamoto Y, Doi M, Otsuru N, Okada G, Takamura M, Ichikawa N, Yokoyama S, Yamashita H, Yamawaki S. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain. Scientific Reports 2017 7: 30003. 57. Kirimoto H, Tamaki H, Otsuru N, Yamashiro K, Onishi H, Nojima I, Oliviero A. Transcranial static magnetic field stimulation over the primary motor cortex induces plastic changes in cortical nociceptive processing. Frontiers Human Neuroscience 2018 12: 63 58. Sasaki R, Nakagawa M, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H: Regulation of primary motor cortex excitability by repetitive passive finger movement frequency. Neuroscience 2017 357: 232-240, 59. Imura T, Tomiyasu M, Otsuru N, Nakagawa K, Otsuka T, Takahasi S, Takeda M, Shrestha L, Kawahara Y, Fukazawa T, Sueda T, Tanimoto K, Yuge L: Hypoxic preconditioning increases the neuroprotective effects of mesenchymal stem cells in a rat model of spinal cord injury. J Stem Cell Res Ther 2017 7: 375, 60. Inukai Y, Saito K, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Masaki M, Otsuru N, Onishi H: Comparison of three non-invasive transcranial electrical stimulation methods for increasing cortical excitability. Front Hum Neurosci 2016 10: 668, 61. Yoshino A, Okamoto Y, Doi M, Horikoshi M, Oshita K, Nakamura R, Otsuru N, Yoshimura S, Tanaka K, Takagaki K, Jinnin R, Yamashita H, Kawamoto M, Yamawaki S: Effectiveness of group cognitive behavioral therapy (GCBT) for somatoform pain disorder patients in Japan: A preliminary non-case-control study. Psychiat Clin Neurosci 2015 69: 763-772, 62. Nishihara M, Inui K, Morita T, Kodaira M, Mochizuki H, Otsuru N, Motomura E, Ushida T, Kakigi R: Echoic memory: Investigation of its temporal resolution analyzed by auditory offset cortical responses. PLOS ONE 2014 9: e106553, 63. Otsuru N, Hashizume A, Nakamura D, Endo Y, Inui K, Kakigi R, Yuge L: Sensory incongruence leading to hand disownership modulates somatosensory cortical processing. Cortex 2014 58:1-8, 64. Nakagawa K, Otsuru N, Inui K, Kakigi R: Change-related auditory P50: A MEG study. NeuroImage 2014 86:131 -137, 65. Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R: Somatotopic representation of pain in the primary somatosensory cortex (SI) in humans. Clin Neurophysiol 2013 124:1422-1430, 66. Otsuru N, Tsuruhara A, Motomura E, Tanii H, Nishihara M, Inui K, Kakigi R: Effects of acute nicotine on auditory change-related cortical responses. Psychopharmacology 2012 224:327-335, 67. Ohoyama K, Motomura E, Inui K, Nishihara M, Otsuru N, Oi M, Kakigi R, Okada M: Memory-based pre-attentive auditory N1 elicited by sound movement. Neurosci Res 2012 73:248-251, 68. Keceli S, Inui K, Okamoto H, Otsuru N, Kakigi R: Auditory sustained field responses to periodic noise. BMC Neurosci 2012 13: 7, 69. Yamashiro K, Inui K, Otsuru N, Urakawa T, Kakigi R: Temporal window of integration in the somatosensory modality: An MEG study. Clin Neurophysiol 2011 122:2276-2281, 70. Nishihara M, Inui K, Motomura E, Otsuru N, Ushida T, Kakigi R: Auditory N1 as a change-related automatic response. Neurosci Res 2011 71:145-148, 71. Otsuru N, Inui K, Yamashiro K, Urakawa T, Keceli S, Kakigi R: Effects of prior sustained tactile stimulation on the somatosensory response to the sudden change of intensity in humans: an magnetoencephalography study. Neuroscience 2011 182:115 -124, 72. Inui K, Urakawa T, Yamashiro K, Otsuru N, Takeshima Y, Nishihara M, Motomura E, Kida T, Kakigi R: Echoic memory of a single pure tone indexed by change-related brain activity. BMC Neurosci 2010 11:135, 73. Inui K, Urakawa T, Yamashiro K, Otsuru N, Nishihara M, Takeshima Y, Keceli S, Kakigi R: Non-linear laws of echoic memory and auditory change detection in humans. BMC Neurosci 2010 11: 80, 74. Yamashiro K, Inui K, Otsuru N, Kakigi R: Change-related response in the human auditory cortex: An MEG study. Psychophysiology 2010 48:23-30, 75. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Takeshima Y, Kakigi R: Assessing A-delta fiber function with lidocaine using intra-epidermal electrical stimulation. J Pain 2010 11:621-627, 76. Mochizuki H, Inui K, Tanabe HC, Akiyama LF, Otsuru N, Yamashiro K, Sasaki A, Nakata H, Sadato N, Kakigi R: Time course of activity in itch-related brain regions: A combined MEG-fMRI study. J Neurophysiol 2009 102:2657-2666, 77. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Ohsawa I, Takeshima Y, Kakigi R: Selective stimulation of C fibers by an Intra-epidermal needle electrode in humans. The Open Pain Journal 2009 2:53-56, 78. Yamashiro K, Inui K, Otsuru N, Kida T, Kakigi R: Automatic auditory off-response in humans: an MEG study. European Journal of Neuroscience 2009 30:125-131, 79. Yamashiro K, Inui K, Otsuru N, Kida T, Kakigi R: Somatosensory off response in humans: an MEG study. NeuroImage 2009 44:1363-1368, 80. Yamashiro K, Inui K, Otsuru N, Kida T, Akatsuka K, Kakigi R: Somatosensory off response in humans: an ERP study. Exp Brain Res 2008 190:207-213, 81. Mochizuki H, Inui K, Yamashiro K, Otsuru N, Kakigi R: Itching-related somatosensory evoked potentials. Pain 2008 138:598-603, |